Complementarity-determining region clustering may cause CAR-T cell dysfunction

Chimeric antigen receptor (CAR)-T cell therapy is rapidly advancing as cancer treatment, however, designing an optimal CAR remains challenging. A single-chain variable fragment (scFv) is generally used as CAR targeting moiety, wherein the complementarity-determining regions (CDRs) define its specifi...

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Detalles Bibliográficos
Autores principales: Sarén, Tina, Saronio, Giulia, Marti Torrell, Paula, Zhu, Xu, Thelander, Josefin, Andersson, Yasmin, Hofström, Camilla, Nestor, Marika, Dimberg, Anna, Persson, Helena, Ramachandran, Mohanraj, Yu, Di, Essand, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415375/
https://www.ncbi.nlm.nih.gov/pubmed/37563127
http://dx.doi.org/10.1038/s41467-023-40303-z

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