Protective antibody threshold of RTS,S/AS01 malaria vaccine correlates antigen and adjuvant dose in mouse model

Mouse models are useful for the early down-selection of malaria vaccine candidates. The Walter Reed Army Institute of Research has optimized a transgenic Plasmodium berghei sporozoite challenge model to compare the efficacy of Plasmodium falciparum circumsporozoite protein (CSP) vaccines. GSK’s RTS,...

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Detalles Bibliográficos
Autores principales: Genito, Christopher J., Brooks, Katherine, Smith, Alexis, Ryan, Emma, Soto, Kim, Li, Yuanzhang, Warter, Lucile, Dutta, Sheetij
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415390/
https://www.ncbi.nlm.nih.gov/pubmed/37563255
http://dx.doi.org/10.1038/s41541-023-00714-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415390/
https://www.ncbi.nlm.nih.gov/pubmed/37563255
http://dx.doi.org/10.1038/s41541-023-00714-x

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