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Apparent diffusion coefficient correlates with different histopathological features in several intrahepatic tumors

OBJECTIVES: To investigate associations between apparent diffusion coefficient (ADC) and cell count, Ki 67, tumor-stroma ratio (TSR), and tumoral lymphocytes in different hepatic malignancies. METHODS: We identified 149 cases with performed liver biopsies: hepatocellular cancer (HCC, n = 53), intrah...

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Autores principales: Surov, Alexey, Eger, Kai Ina, Potratz, Johann, Gottschling, Sebastian, Wienke, Andreas, Jechorek, Dörthe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415451/
https://www.ncbi.nlm.nih.gov/pubmed/37347430
http://dx.doi.org/10.1007/s00330-023-09788-6
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author Surov, Alexey
Eger, Kai Ina
Potratz, Johann
Gottschling, Sebastian
Wienke, Andreas
Jechorek, Dörthe
author_facet Surov, Alexey
Eger, Kai Ina
Potratz, Johann
Gottschling, Sebastian
Wienke, Andreas
Jechorek, Dörthe
author_sort Surov, Alexey
collection PubMed
description OBJECTIVES: To investigate associations between apparent diffusion coefficient (ADC) and cell count, Ki 67, tumor-stroma ratio (TSR), and tumoral lymphocytes in different hepatic malignancies. METHODS: We identified 149 cases with performed liver biopsies: hepatocellular cancer (HCC, n = 53), intrahepatic cholangiocarcinoma (iCC, n = 29), metastases of colorectal cancer (CRC, n = 24), metastases of breast cancer (BC, n = 28), and metastases of pancreatic cancer (PC, n = 15). MRI was performed on a 1.5-T scanner with an axial echo-planar sequence. MRI was done before biopsy. Biopsy images of target lesions were selected. The cylindrical region of interest was placed on the ADC map of target lesions in accordance with the needle position on the biopsy images. Mean ADC values were estimated. TSR, cell counts, proliferation index Ki 67, and number of tumor-infiltrating lymphocytes were estimated. Spearman’s rank correlation coefficients and intraclass correlation coefficients were calculated. RESULTS: Inter-reader agreement was excellent regarding the ADC measurements. In HCC, ADC correlated with cell count (r =  − 0.68, p < 0.001) and with TSR (r = 0.31, p = 0.024). In iCC, ADC correlated with TSR (r = 0.60, p < 0.001) and with cell count (r =  − 0.54, p = 0.002). In CRC metastases, ADC correlated with cell count (r =  − 0.54 p = 0.006) and with Ki 67 (r =  − 0.46, p = 0.024). In BC liver metastases, ADC correlated with TSR (r = 0.55, p < 0.002) and with Ki 67 (r =  − 0.51, p = 0.006). In PC metastases, no significant correlations were found. CONCLUSIONS: ADC correlated with tumor cellularity in HCC, iCC, and CRC liver metastases. ADC reflects TSR in BC liver metastases, HCC, and iCC. ADC cannot reflect intratumoral lymphocytes. CLINICAL RELEVANCE STATEMENT: The present study shows that the apparent diffusion coefficient can be used as a surrogate imaging marker for different histopathological features in several malignant hepatic lesions. KEY POINTS: • ADC reflects different histopathological features in several hepatic tumors. • ADC correlates with tumor cellularity in HCC, iCC, and CRC metastases. • ADC strongly correlates with tumor-stroma ratio in BC metastases and iCC.
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spelling pubmed-104154512023-08-12 Apparent diffusion coefficient correlates with different histopathological features in several intrahepatic tumors Surov, Alexey Eger, Kai Ina Potratz, Johann Gottschling, Sebastian Wienke, Andreas Jechorek, Dörthe Eur Radiol Hepatobiliary-Pancreas OBJECTIVES: To investigate associations between apparent diffusion coefficient (ADC) and cell count, Ki 67, tumor-stroma ratio (TSR), and tumoral lymphocytes in different hepatic malignancies. METHODS: We identified 149 cases with performed liver biopsies: hepatocellular cancer (HCC, n = 53), intrahepatic cholangiocarcinoma (iCC, n = 29), metastases of colorectal cancer (CRC, n = 24), metastases of breast cancer (BC, n = 28), and metastases of pancreatic cancer (PC, n = 15). MRI was performed on a 1.5-T scanner with an axial echo-planar sequence. MRI was done before biopsy. Biopsy images of target lesions were selected. The cylindrical region of interest was placed on the ADC map of target lesions in accordance with the needle position on the biopsy images. Mean ADC values were estimated. TSR, cell counts, proliferation index Ki 67, and number of tumor-infiltrating lymphocytes were estimated. Spearman’s rank correlation coefficients and intraclass correlation coefficients were calculated. RESULTS: Inter-reader agreement was excellent regarding the ADC measurements. In HCC, ADC correlated with cell count (r =  − 0.68, p < 0.001) and with TSR (r = 0.31, p = 0.024). In iCC, ADC correlated with TSR (r = 0.60, p < 0.001) and with cell count (r =  − 0.54, p = 0.002). In CRC metastases, ADC correlated with cell count (r =  − 0.54 p = 0.006) and with Ki 67 (r =  − 0.46, p = 0.024). In BC liver metastases, ADC correlated with TSR (r = 0.55, p < 0.002) and with Ki 67 (r =  − 0.51, p = 0.006). In PC metastases, no significant correlations were found. CONCLUSIONS: ADC correlated with tumor cellularity in HCC, iCC, and CRC liver metastases. ADC reflects TSR in BC liver metastases, HCC, and iCC. ADC cannot reflect intratumoral lymphocytes. CLINICAL RELEVANCE STATEMENT: The present study shows that the apparent diffusion coefficient can be used as a surrogate imaging marker for different histopathological features in several malignant hepatic lesions. KEY POINTS: • ADC reflects different histopathological features in several hepatic tumors. • ADC correlates with tumor cellularity in HCC, iCC, and CRC metastases. • ADC strongly correlates with tumor-stroma ratio in BC metastases and iCC. Springer Berlin Heidelberg 2023-06-22 2023 /pmc/articles/PMC10415451/ /pubmed/37347430 http://dx.doi.org/10.1007/s00330-023-09788-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Hepatobiliary-Pancreas
Surov, Alexey
Eger, Kai Ina
Potratz, Johann
Gottschling, Sebastian
Wienke, Andreas
Jechorek, Dörthe
Apparent diffusion coefficient correlates with different histopathological features in several intrahepatic tumors
title Apparent diffusion coefficient correlates with different histopathological features in several intrahepatic tumors
title_full Apparent diffusion coefficient correlates with different histopathological features in several intrahepatic tumors
title_fullStr Apparent diffusion coefficient correlates with different histopathological features in several intrahepatic tumors
title_full_unstemmed Apparent diffusion coefficient correlates with different histopathological features in several intrahepatic tumors
title_short Apparent diffusion coefficient correlates with different histopathological features in several intrahepatic tumors
title_sort apparent diffusion coefficient correlates with different histopathological features in several intrahepatic tumors
topic Hepatobiliary-Pancreas
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415451/
https://www.ncbi.nlm.nih.gov/pubmed/37347430
http://dx.doi.org/10.1007/s00330-023-09788-6
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