Reduced Cerebellar BDNF Availability Affects Postnatal Differentiation and Maturation of Granule Cells in a Mouse Model of Cholesterol Dyshomeostasis

Niemann-Pick type C1 (NPC1) disease is a lysosomal lipid storage disorder due to mutations in the NPC1 gene resulting in the accumulation of cholesterol within the endosomal/lysosomal compartments. The prominent feature of the disorder is the progressive Purkinje cell degeneration leading to ataxia....

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Detalles Bibliográficos
Autores principales: Lucarelli, Micaela, Camuso, Serena, Di Pietro, Chiara, Bruno, Francesco, La Rosa, Piergiorgio, Marazziti, Daniela, Fiorenza, Maria Teresa, Canterini, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415459/
https://www.ncbi.nlm.nih.gov/pubmed/37314654
http://dx.doi.org/10.1007/s12035-023-03435-3

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