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Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?

Both individuals taking rapamycin, an anti-aging drug, and those not taking it will ultimately succumb to age-related diseases. However, the former, if administered disease-oriented dosages for a long time, may experience a delayed onset of such diseases and live longer. The goal is to delay a parti...

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Autor principal: Blagosklonny, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415559/
https://www.ncbi.nlm.nih.gov/pubmed/37477535
http://dx.doi.org/10.18632/aging.204920
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author Blagosklonny, Mikhail V.
author_facet Blagosklonny, Mikhail V.
author_sort Blagosklonny, Mikhail V.
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description Both individuals taking rapamycin, an anti-aging drug, and those not taking it will ultimately succumb to age-related diseases. However, the former, if administered disease-oriented dosages for a long time, may experience a delayed onset of such diseases and live longer. The goal is to delay a particular disease that is expected to be life-limiting in a particular person. Age-related diseases, quasi-programmed during development, progress at varying rates in different individuals. Rapamycin is a prophylactic anti-aging drug that decelerates early development of age-related diseases. I further discuss hyperfunction theory of quasi-programmed diseases, which challenges the need for the traditional concept of aging itself.
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spelling pubmed-104155592023-08-12 Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases? Blagosklonny, Mikhail V. Aging (Albany NY) Research Perspective Both individuals taking rapamycin, an anti-aging drug, and those not taking it will ultimately succumb to age-related diseases. However, the former, if administered disease-oriented dosages for a long time, may experience a delayed onset of such diseases and live longer. The goal is to delay a particular disease that is expected to be life-limiting in a particular person. Age-related diseases, quasi-programmed during development, progress at varying rates in different individuals. Rapamycin is a prophylactic anti-aging drug that decelerates early development of age-related diseases. I further discuss hyperfunction theory of quasi-programmed diseases, which challenges the need for the traditional concept of aging itself. Impact Journals 2023-07-20 /pmc/articles/PMC10415559/ /pubmed/37477535 http://dx.doi.org/10.18632/aging.204920 Text en Copyright: © 2023 Blagosklonny. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Perspective
Blagosklonny, Mikhail V.
Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?
title Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?
title_full Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?
title_fullStr Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?
title_full_unstemmed Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?
title_short Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?
title_sort towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415559/
https://www.ncbi.nlm.nih.gov/pubmed/37477535
http://dx.doi.org/10.18632/aging.204920
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