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Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?
Both individuals taking rapamycin, an anti-aging drug, and those not taking it will ultimately succumb to age-related diseases. However, the former, if administered disease-oriented dosages for a long time, may experience a delayed onset of such diseases and live longer. The goal is to delay a parti...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Impact Journals
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415559/ https://www.ncbi.nlm.nih.gov/pubmed/37477535 http://dx.doi.org/10.18632/aging.204920 |
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author | Blagosklonny, Mikhail V. |
author_facet | Blagosklonny, Mikhail V. |
author_sort | Blagosklonny, Mikhail V. |
collection | PubMed |
description | Both individuals taking rapamycin, an anti-aging drug, and those not taking it will ultimately succumb to age-related diseases. However, the former, if administered disease-oriented dosages for a long time, may experience a delayed onset of such diseases and live longer. The goal is to delay a particular disease that is expected to be life-limiting in a particular person. Age-related diseases, quasi-programmed during development, progress at varying rates in different individuals. Rapamycin is a prophylactic anti-aging drug that decelerates early development of age-related diseases. I further discuss hyperfunction theory of quasi-programmed diseases, which challenges the need for the traditional concept of aging itself. |
format | Online Article Text |
id | pubmed-10415559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-104155592023-08-12 Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases? Blagosklonny, Mikhail V. Aging (Albany NY) Research Perspective Both individuals taking rapamycin, an anti-aging drug, and those not taking it will ultimately succumb to age-related diseases. However, the former, if administered disease-oriented dosages for a long time, may experience a delayed onset of such diseases and live longer. The goal is to delay a particular disease that is expected to be life-limiting in a particular person. Age-related diseases, quasi-programmed during development, progress at varying rates in different individuals. Rapamycin is a prophylactic anti-aging drug that decelerates early development of age-related diseases. I further discuss hyperfunction theory of quasi-programmed diseases, which challenges the need for the traditional concept of aging itself. Impact Journals 2023-07-20 /pmc/articles/PMC10415559/ /pubmed/37477535 http://dx.doi.org/10.18632/aging.204920 Text en Copyright: © 2023 Blagosklonny. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Perspective Blagosklonny, Mikhail V. Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases? |
title | Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases? |
title_full | Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases? |
title_fullStr | Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases? |
title_full_unstemmed | Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases? |
title_short | Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases? |
title_sort | towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases? |
topic | Research Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415559/ https://www.ncbi.nlm.nih.gov/pubmed/37477535 http://dx.doi.org/10.18632/aging.204920 |
work_keys_str_mv | AT blagosklonnymikhailv towardsdiseaseorienteddosingofrapamycinforlongevitydoesagingexistoronlyagerelateddiseases |