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CRISPR interference provides increased cell type-specificity compared to the Cre-loxP system

Cre-mediated recombination is frequently used for cell type-specific loss of function (LOF) studies. A major limitation of this system is recombination in unwanted cell types. CRISPR interference (CRISPRi) has been used effectively for global LOF in mice. However, cell type-specific CRISPRi, indepen...

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Detalles Bibliográficos
Autores principales:	Laster, Dominique J., Akel, Nisreen S., Hendrixson, James A., James, Alicen, Crawford, Julie A., Fu, Qiang, Berryhill, Stuart B., Thostenson, Jeff D., Nookaew, Intawat, O’Brien, Charles A., Onal, Melda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415806/ https://www.ncbi.nlm.nih.gov/pubmed/37575184 http://dx.doi.org/10.1016/j.isci.2023.107428

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