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Altered interhemispheric functional connectivity in patients with comitant exotropia before and after surgery: a resting-state fMRI study
PURPOSE: To assess the interhemispheric homotopic connectivity alterations in patients with comitant exotropia (CE) before and after surgery, using resting-state functional magnetic resonance imaging (rs-fMRI) with voxel-mirrored homotopic connectivity (VMHC). METHODS: Thirty-four patients with CE a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416095/ https://www.ncbi.nlm.nih.gov/pubmed/37576471 http://dx.doi.org/10.3389/fnhum.2023.1095431 |
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author | Chen, Xiang-Xun Chen, Wen Hu, Hao Zhao, Meng Liu, Hu Xu, Xiao-Quan Wu, Fei-Yun Wang, Jie |
author_facet | Chen, Xiang-Xun Chen, Wen Hu, Hao Zhao, Meng Liu, Hu Xu, Xiao-Quan Wu, Fei-Yun Wang, Jie |
author_sort | Chen, Xiang-Xun |
collection | PubMed |
description | PURPOSE: To assess the interhemispheric homotopic connectivity alterations in patients with comitant exotropia (CE) before and after surgery, using resting-state functional magnetic resonance imaging (rs-fMRI) with voxel-mirrored homotopic connectivity (VMHC). METHODS: Thirty-four patients with CE and twenty-four well-matched healthy controls (HCs) were enrolled to undergo a preoperative rs-fMRI scan. The rs-fMRI scan was performed again in twenty-four patients 1 month after surgery. The VMHC method was applied to evaluate the group differences of interhemispheric functional connectivity. The correlations between VMHC values and clinical variables were analyzed in the patient group. RESULTS: Compared with HCs, 34 patients with CE showed significantly increased VMHC values in occipital lobe (cuneus/superior occipital gyrus/middle occipital gyrus/calcarine), cerebellar area 8/cerebellar Crus1 area, and cerebellar Crus1 area. In CE group, VMHC in the cuneus was positively correlated with stereoacuity (r = 0.417, P = 0.014), meanwhile VMHC in the cerebellar Crus1 area was positively correlated with stereoacuity (r = 0.395, P = 0.021). One month after surgery, the 24 CE patients with follow-up showed decreased VMHC values in the cuneus and superior occipital gyrus compared with preoperative collection, meanwhile, non-significant difference compared with HCs. CONCLUSION: Our study revealed the interhemispheric homotopic connectivity changes of patients with CE in the occipital lobe and cerebellum before and after surgery. The findings may provide a new perspective for the neurological alterations of CE. |
format | Online Article Text |
id | pubmed-10416095 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104160952023-08-12 Altered interhemispheric functional connectivity in patients with comitant exotropia before and after surgery: a resting-state fMRI study Chen, Xiang-Xun Chen, Wen Hu, Hao Zhao, Meng Liu, Hu Xu, Xiao-Quan Wu, Fei-Yun Wang, Jie Front Hum Neurosci Neuroscience PURPOSE: To assess the interhemispheric homotopic connectivity alterations in patients with comitant exotropia (CE) before and after surgery, using resting-state functional magnetic resonance imaging (rs-fMRI) with voxel-mirrored homotopic connectivity (VMHC). METHODS: Thirty-four patients with CE and twenty-four well-matched healthy controls (HCs) were enrolled to undergo a preoperative rs-fMRI scan. The rs-fMRI scan was performed again in twenty-four patients 1 month after surgery. The VMHC method was applied to evaluate the group differences of interhemispheric functional connectivity. The correlations between VMHC values and clinical variables were analyzed in the patient group. RESULTS: Compared with HCs, 34 patients with CE showed significantly increased VMHC values in occipital lobe (cuneus/superior occipital gyrus/middle occipital gyrus/calcarine), cerebellar area 8/cerebellar Crus1 area, and cerebellar Crus1 area. In CE group, VMHC in the cuneus was positively correlated with stereoacuity (r = 0.417, P = 0.014), meanwhile VMHC in the cerebellar Crus1 area was positively correlated with stereoacuity (r = 0.395, P = 0.021). One month after surgery, the 24 CE patients with follow-up showed decreased VMHC values in the cuneus and superior occipital gyrus compared with preoperative collection, meanwhile, non-significant difference compared with HCs. CONCLUSION: Our study revealed the interhemispheric homotopic connectivity changes of patients with CE in the occipital lobe and cerebellum before and after surgery. The findings may provide a new perspective for the neurological alterations of CE. Frontiers Media S.A. 2023-07-27 /pmc/articles/PMC10416095/ /pubmed/37576471 http://dx.doi.org/10.3389/fnhum.2023.1095431 Text en Copyright © 2023 Chen, Chen, Hu, Zhao, Liu, Xu, Wu and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Chen, Xiang-Xun Chen, Wen Hu, Hao Zhao, Meng Liu, Hu Xu, Xiao-Quan Wu, Fei-Yun Wang, Jie Altered interhemispheric functional connectivity in patients with comitant exotropia before and after surgery: a resting-state fMRI study |
title | Altered interhemispheric functional connectivity in patients with comitant exotropia before and after surgery: a resting-state fMRI study |
title_full | Altered interhemispheric functional connectivity in patients with comitant exotropia before and after surgery: a resting-state fMRI study |
title_fullStr | Altered interhemispheric functional connectivity in patients with comitant exotropia before and after surgery: a resting-state fMRI study |
title_full_unstemmed | Altered interhemispheric functional connectivity in patients with comitant exotropia before and after surgery: a resting-state fMRI study |
title_short | Altered interhemispheric functional connectivity in patients with comitant exotropia before and after surgery: a resting-state fMRI study |
title_sort | altered interhemispheric functional connectivity in patients with comitant exotropia before and after surgery: a resting-state fmri study |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416095/ https://www.ncbi.nlm.nih.gov/pubmed/37576471 http://dx.doi.org/10.3389/fnhum.2023.1095431 |
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