Senolytic therapy is neuroprotective and improves functional outcome long-term after traumatic brain injury in mice

INTRODUCTION: Chronic neuroinflammation can exist for months to years following traumatic brain injury (TBI), although the underlying mechanisms remain poorly understood. METHODS: In the current study, we used a controlled cortical impact mouse model of TBI to examine whether proinflammatory senesce...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Lu, Yujiao, Carr, Christopher, Dhandapani, Krishnan M., Brann, Darrell W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416099/
https://www.ncbi.nlm.nih.gov/pubmed/37575310
http://dx.doi.org/10.3389/fnins.2023.1227705

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