Cargando…

Presenilins and mitochondria—an intriguing link: mini-review

This review uncovers the intricate relationship between presenilins, calcium, and mitochondria in the context of Alzheimer’s disease (AD), with a particular focus on the involvement of presenilin mutations in mitochondrial dysfunction. So far, it is unclear whether the impairment of mitochondrial fu...

Descripción completa

Detalles Bibliográficos
Autores principales: Makarov, Mark, Kushnireva, Liliia, Papa, Michele, Korkotian, Eduard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416233/
https://www.ncbi.nlm.nih.gov/pubmed/37575294
http://dx.doi.org/10.3389/fnins.2023.1249815
_version_ 1785087726750531584
author Makarov, Mark
Kushnireva, Liliia
Papa, Michele
Korkotian, Eduard
author_facet Makarov, Mark
Kushnireva, Liliia
Papa, Michele
Korkotian, Eduard
author_sort Makarov, Mark
collection PubMed
description This review uncovers the intricate relationship between presenilins, calcium, and mitochondria in the context of Alzheimer’s disease (AD), with a particular focus on the involvement of presenilin mutations in mitochondrial dysfunction. So far, it is unclear whether the impairment of mitochondrial function arises primarily from damage inflicted by β-amyloid upon mitochondria or from the disruption of calcium homeostasis due to presenilins dysfunctions. The roles of presenilins in mitophagy, autophagy, mitochondrial dynamics, and many other functions, non-γ-secretase related, also require close attention in future research. Resolution of contradictions in understanding of presenilins cellular functions are needed for new effective therapeutic strategies for AD.
format Online
Article
Text
id pubmed-10416233
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-104162332023-08-12 Presenilins and mitochondria—an intriguing link: mini-review Makarov, Mark Kushnireva, Liliia Papa, Michele Korkotian, Eduard Front Neurosci Neuroscience This review uncovers the intricate relationship between presenilins, calcium, and mitochondria in the context of Alzheimer’s disease (AD), with a particular focus on the involvement of presenilin mutations in mitochondrial dysfunction. So far, it is unclear whether the impairment of mitochondrial function arises primarily from damage inflicted by β-amyloid upon mitochondria or from the disruption of calcium homeostasis due to presenilins dysfunctions. The roles of presenilins in mitophagy, autophagy, mitochondrial dynamics, and many other functions, non-γ-secretase related, also require close attention in future research. Resolution of contradictions in understanding of presenilins cellular functions are needed for new effective therapeutic strategies for AD. Frontiers Media S.A. 2023-07-28 /pmc/articles/PMC10416233/ /pubmed/37575294 http://dx.doi.org/10.3389/fnins.2023.1249815 Text en Copyright © 2023 Makarov, Kushnireva, Papa and Korkotian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Makarov, Mark
Kushnireva, Liliia
Papa, Michele
Korkotian, Eduard
Presenilins and mitochondria—an intriguing link: mini-review
title Presenilins and mitochondria—an intriguing link: mini-review
title_full Presenilins and mitochondria—an intriguing link: mini-review
title_fullStr Presenilins and mitochondria—an intriguing link: mini-review
title_full_unstemmed Presenilins and mitochondria—an intriguing link: mini-review
title_short Presenilins and mitochondria—an intriguing link: mini-review
title_sort presenilins and mitochondria—an intriguing link: mini-review
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416233/
https://www.ncbi.nlm.nih.gov/pubmed/37575294
http://dx.doi.org/10.3389/fnins.2023.1249815
work_keys_str_mv AT makarovmark presenilinsandmitochondriaanintriguinglinkminireview
AT kushnirevaliliia presenilinsandmitochondriaanintriguinglinkminireview
AT papamichele presenilinsandmitochondriaanintriguinglinkminireview
AT korkotianeduard presenilinsandmitochondriaanintriguinglinkminireview