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The regulation of lncRNAs and miRNAs in SARS-CoV-2 infection

The coronavirus disease 2019 (COVID-19) was a global endemic that continues to cause a large number of severe illnesses and fatalities. There is increasing evidence that non-coding RNAs (ncRNAs) are crucial regulators of viral infection and antiviral immune response and the role of non-coding RNAs i...

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Autores principales: Lin, Yuhao, Sun, Qiqi, Zhang, Bao, Zhao, Wei, Shen, Chenguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416254/
https://www.ncbi.nlm.nih.gov/pubmed/37576600
http://dx.doi.org/10.3389/fcell.2023.1229393
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author Lin, Yuhao
Sun, Qiqi
Zhang, Bao
Zhao, Wei
Shen, Chenguang
author_facet Lin, Yuhao
Sun, Qiqi
Zhang, Bao
Zhao, Wei
Shen, Chenguang
author_sort Lin, Yuhao
collection PubMed
description The coronavirus disease 2019 (COVID-19) was a global endemic that continues to cause a large number of severe illnesses and fatalities. There is increasing evidence that non-coding RNAs (ncRNAs) are crucial regulators of viral infection and antiviral immune response and the role of non-coding RNAs in SARS-CoV-2 infection has now become the focus of scholarly inquiry. After SARS-CoV-2 infection, some ncRNAs’ expression levels are regulated to indirectly control the expression of antiviral genes and viral gene replication. However, some other ncRNAs are hijacked by SARS-CoV-2 in order to help the virus evade the immune system by suppressing the expression of type I interferon (IFN-1) and controlling cytokine levels. In this review, we summarize the recent findings of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) among non-coding RNAs in SARS-CoV-2 infection and antiviral response, discuss the potential mechanisms of actions, and prospects for the detection, treatment, prevention and future directions of SARS-CoV-2 infection research.
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spelling pubmed-104162542023-08-12 The regulation of lncRNAs and miRNAs in SARS-CoV-2 infection Lin, Yuhao Sun, Qiqi Zhang, Bao Zhao, Wei Shen, Chenguang Front Cell Dev Biol Cell and Developmental Biology The coronavirus disease 2019 (COVID-19) was a global endemic that continues to cause a large number of severe illnesses and fatalities. There is increasing evidence that non-coding RNAs (ncRNAs) are crucial regulators of viral infection and antiviral immune response and the role of non-coding RNAs in SARS-CoV-2 infection has now become the focus of scholarly inquiry. After SARS-CoV-2 infection, some ncRNAs’ expression levels are regulated to indirectly control the expression of antiviral genes and viral gene replication. However, some other ncRNAs are hijacked by SARS-CoV-2 in order to help the virus evade the immune system by suppressing the expression of type I interferon (IFN-1) and controlling cytokine levels. In this review, we summarize the recent findings of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) among non-coding RNAs in SARS-CoV-2 infection and antiviral response, discuss the potential mechanisms of actions, and prospects for the detection, treatment, prevention and future directions of SARS-CoV-2 infection research. Frontiers Media S.A. 2023-07-27 /pmc/articles/PMC10416254/ /pubmed/37576600 http://dx.doi.org/10.3389/fcell.2023.1229393 Text en Copyright © 2023 Lin, Sun, Zhang, Zhao and Shen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Lin, Yuhao
Sun, Qiqi
Zhang, Bao
Zhao, Wei
Shen, Chenguang
The regulation of lncRNAs and miRNAs in SARS-CoV-2 infection
title The regulation of lncRNAs and miRNAs in SARS-CoV-2 infection
title_full The regulation of lncRNAs and miRNAs in SARS-CoV-2 infection
title_fullStr The regulation of lncRNAs and miRNAs in SARS-CoV-2 infection
title_full_unstemmed The regulation of lncRNAs and miRNAs in SARS-CoV-2 infection
title_short The regulation of lncRNAs and miRNAs in SARS-CoV-2 infection
title_sort regulation of lncrnas and mirnas in sars-cov-2 infection
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416254/
https://www.ncbi.nlm.nih.gov/pubmed/37576600
http://dx.doi.org/10.3389/fcell.2023.1229393
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