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Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention

OBJECTIVES: This study aimed to examine possible associations between previously undiagnosed subclinical hypothyroidism and short-term outcomes and mortality in a sample of Iraqi patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. DESIGN: Th...

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Autores principales: al-Gburi, Abdulameer J, al-Obaidi, Saba R, Abdullah, Wasnaa H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ghana Medical Association 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416275/
https://www.ncbi.nlm.nih.gov/pubmed/37576368
http://dx.doi.org/10.4314/gmj.v57i1.6
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author al-Gburi, Abdulameer J
al-Obaidi, Saba R
Abdullah, Wasnaa H
author_facet al-Gburi, Abdulameer J
al-Obaidi, Saba R
Abdullah, Wasnaa H
author_sort al-Gburi, Abdulameer J
collection PubMed
description OBJECTIVES: This study aimed to examine possible associations between previously undiagnosed subclinical hypothyroidism and short-term outcomes and mortality in a sample of Iraqi patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. DESIGN: This is a prospective observational cohort study. SETTING: The study was conducted in a single tertiary referral centre in Baghdad, Iraq. PARTICIPANTS: Thyroid-stimulating hormone and free T4 levels were measured in 257 patients hospitalised with ST-elevation myocardial infarction who underwent primary percutaneous coronary intervention between January 2020 and March 2022. MAIN OUTCOME MEASURES: Adverse cardiovascular and renal events during hospitalisation and 30-day mortality were observed. RESULTS: Previously undiagnosed subclinical hypothyroidism was detected in 36/257 (14%) ST-elevation myocardial infarction patients and observed more commonly in females than males. Patients with subclinical hypothyroidism had significantly worse short-term outcomes, including higher rates of suboptimal TIMI Flow (< III) (p =0.014), left ventricular ejection fraction ≤ 40% (p=0.035), Killip class >I (p=0.042), cardiogenic shock (p =0.016), cardiac arrest in the hospital (p= 0.01), and acute kidney injury (p= 0.044). Additionally, 30-day mortality was significantly higher in patients with subclinical hypothyroidism (p= 0.029). CONCLUSION: Subclinical hypothyroidism previously undiagnosed and untreated had a significant association with adverse short-term outcomes and higher short-term mortality within 30 days compared to euthyroid patients undergoing primary percutaneous coronary intervention. Routine thyroid function testing during these patients' hospitalisation may be warranted. FUNDING: None declared
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spelling pubmed-104162752023-08-12 Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention al-Gburi, Abdulameer J al-Obaidi, Saba R Abdullah, Wasnaa H Ghana Med J Original Article OBJECTIVES: This study aimed to examine possible associations between previously undiagnosed subclinical hypothyroidism and short-term outcomes and mortality in a sample of Iraqi patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. DESIGN: This is a prospective observational cohort study. SETTING: The study was conducted in a single tertiary referral centre in Baghdad, Iraq. PARTICIPANTS: Thyroid-stimulating hormone and free T4 levels were measured in 257 patients hospitalised with ST-elevation myocardial infarction who underwent primary percutaneous coronary intervention between January 2020 and March 2022. MAIN OUTCOME MEASURES: Adverse cardiovascular and renal events during hospitalisation and 30-day mortality were observed. RESULTS: Previously undiagnosed subclinical hypothyroidism was detected in 36/257 (14%) ST-elevation myocardial infarction patients and observed more commonly in females than males. Patients with subclinical hypothyroidism had significantly worse short-term outcomes, including higher rates of suboptimal TIMI Flow (< III) (p =0.014), left ventricular ejection fraction ≤ 40% (p=0.035), Killip class >I (p=0.042), cardiogenic shock (p =0.016), cardiac arrest in the hospital (p= 0.01), and acute kidney injury (p= 0.044). Additionally, 30-day mortality was significantly higher in patients with subclinical hypothyroidism (p= 0.029). CONCLUSION: Subclinical hypothyroidism previously undiagnosed and untreated had a significant association with adverse short-term outcomes and higher short-term mortality within 30 days compared to euthyroid patients undergoing primary percutaneous coronary intervention. Routine thyroid function testing during these patients' hospitalisation may be warranted. FUNDING: None declared Ghana Medical Association 2023-01 /pmc/articles/PMC10416275/ /pubmed/37576368 http://dx.doi.org/10.4314/gmj.v57i1.6 Text en Copyright © The Author(s). https://creativecommons.org/licenses/by/4.0/This is an Open Access article under the CC BY license.
spellingShingle Original Article
al-Gburi, Abdulameer J
al-Obaidi, Saba R
Abdullah, Wasnaa H
Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention
title Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention
title_full Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention
title_fullStr Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention
title_full_unstemmed Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention
title_short Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention
title_sort short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416275/
https://www.ncbi.nlm.nih.gov/pubmed/37576368
http://dx.doi.org/10.4314/gmj.v57i1.6
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