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Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention
OBJECTIVES: This study aimed to examine possible associations between previously undiagnosed subclinical hypothyroidism and short-term outcomes and mortality in a sample of Iraqi patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. DESIGN: Th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ghana Medical Association
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416275/ https://www.ncbi.nlm.nih.gov/pubmed/37576368 http://dx.doi.org/10.4314/gmj.v57i1.6 |
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author | al-Gburi, Abdulameer J al-Obaidi, Saba R Abdullah, Wasnaa H |
author_facet | al-Gburi, Abdulameer J al-Obaidi, Saba R Abdullah, Wasnaa H |
author_sort | al-Gburi, Abdulameer J |
collection | PubMed |
description | OBJECTIVES: This study aimed to examine possible associations between previously undiagnosed subclinical hypothyroidism and short-term outcomes and mortality in a sample of Iraqi patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. DESIGN: This is a prospective observational cohort study. SETTING: The study was conducted in a single tertiary referral centre in Baghdad, Iraq. PARTICIPANTS: Thyroid-stimulating hormone and free T4 levels were measured in 257 patients hospitalised with ST-elevation myocardial infarction who underwent primary percutaneous coronary intervention between January 2020 and March 2022. MAIN OUTCOME MEASURES: Adverse cardiovascular and renal events during hospitalisation and 30-day mortality were observed. RESULTS: Previously undiagnosed subclinical hypothyroidism was detected in 36/257 (14%) ST-elevation myocardial infarction patients and observed more commonly in females than males. Patients with subclinical hypothyroidism had significantly worse short-term outcomes, including higher rates of suboptimal TIMI Flow (< III) (p =0.014), left ventricular ejection fraction ≤ 40% (p=0.035), Killip class >I (p=0.042), cardiogenic shock (p =0.016), cardiac arrest in the hospital (p= 0.01), and acute kidney injury (p= 0.044). Additionally, 30-day mortality was significantly higher in patients with subclinical hypothyroidism (p= 0.029). CONCLUSION: Subclinical hypothyroidism previously undiagnosed and untreated had a significant association with adverse short-term outcomes and higher short-term mortality within 30 days compared to euthyroid patients undergoing primary percutaneous coronary intervention. Routine thyroid function testing during these patients' hospitalisation may be warranted. FUNDING: None declared |
format | Online Article Text |
id | pubmed-10416275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Ghana Medical Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-104162752023-08-12 Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention al-Gburi, Abdulameer J al-Obaidi, Saba R Abdullah, Wasnaa H Ghana Med J Original Article OBJECTIVES: This study aimed to examine possible associations between previously undiagnosed subclinical hypothyroidism and short-term outcomes and mortality in a sample of Iraqi patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. DESIGN: This is a prospective observational cohort study. SETTING: The study was conducted in a single tertiary referral centre in Baghdad, Iraq. PARTICIPANTS: Thyroid-stimulating hormone and free T4 levels were measured in 257 patients hospitalised with ST-elevation myocardial infarction who underwent primary percutaneous coronary intervention between January 2020 and March 2022. MAIN OUTCOME MEASURES: Adverse cardiovascular and renal events during hospitalisation and 30-day mortality were observed. RESULTS: Previously undiagnosed subclinical hypothyroidism was detected in 36/257 (14%) ST-elevation myocardial infarction patients and observed more commonly in females than males. Patients with subclinical hypothyroidism had significantly worse short-term outcomes, including higher rates of suboptimal TIMI Flow (< III) (p =0.014), left ventricular ejection fraction ≤ 40% (p=0.035), Killip class >I (p=0.042), cardiogenic shock (p =0.016), cardiac arrest in the hospital (p= 0.01), and acute kidney injury (p= 0.044). Additionally, 30-day mortality was significantly higher in patients with subclinical hypothyroidism (p= 0.029). CONCLUSION: Subclinical hypothyroidism previously undiagnosed and untreated had a significant association with adverse short-term outcomes and higher short-term mortality within 30 days compared to euthyroid patients undergoing primary percutaneous coronary intervention. Routine thyroid function testing during these patients' hospitalisation may be warranted. FUNDING: None declared Ghana Medical Association 2023-01 /pmc/articles/PMC10416275/ /pubmed/37576368 http://dx.doi.org/10.4314/gmj.v57i1.6 Text en Copyright © The Author(s). https://creativecommons.org/licenses/by/4.0/This is an Open Access article under the CC BY license. |
spellingShingle | Original Article al-Gburi, Abdulameer J al-Obaidi, Saba R Abdullah, Wasnaa H Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention |
title | Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention |
title_full | Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention |
title_fullStr | Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention |
title_full_unstemmed | Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention |
title_short | Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention |
title_sort | short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416275/ https://www.ncbi.nlm.nih.gov/pubmed/37576368 http://dx.doi.org/10.4314/gmj.v57i1.6 |
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