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The correlation between multiple HPV infections and the occurrence, development, and prognosis of cervical cancer
Cervical carcinoma is the fourth female malignant tumor in the world, and the persistent infection of high-risk human papillomavirus (HPV) is recognized as the most common cause. This article studies the correlation between multiple HPV infections and the occurrence, development, and prognosis of ce...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416435/ https://www.ncbi.nlm.nih.gov/pubmed/37577444 http://dx.doi.org/10.3389/fmicb.2023.1220522 |
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author | Na, Jing Li, Ya Wang, Jun Wang, Xinyou Lu, JunLing Han, Shichao |
author_facet | Na, Jing Li, Ya Wang, Jun Wang, Xinyou Lu, JunLing Han, Shichao |
author_sort | Na, Jing |
collection | PubMed |
description | Cervical carcinoma is the fourth female malignant tumor in the world, and the persistent infection of high-risk human papillomavirus (HPV) is recognized as the most common cause. This article studies the correlation between multiple HPV infections and the occurrence, development, and prognosis of cervical cancer in order to provide more references for clinical diagnosis and treatment. We conducted a retrospective analysis of the clinical data of 400 cervical carcinoma patients admitted to our hospital from 2015 to 2023. The collected patient data include age, HPV infection status, tumor size and morphology, local infiltration depth, diagnostic staging, surgical approach, vascular cancer thrombus status, lymph node status, and postoperative HPV follow-up status. We use SPSS statistical software for data analysis. Our research shows that the high-risk age group for cervical carcinoma is concentrated between 41 and 60 years old, which is basically consistent with the age range of the high incidence of HPV infection. In the statistics for HPV infection types, ~67.7% of patients are single HPV-infected, 25.29% are double infected, and 7.00% are infected with three or more types of HPV. Among the multiple HPV infections, most of the patients are younger than 40 years old and older than 70 years old, with double infection accounting for the majority. The top five HPV subtypes with high detection rates belong to high-risk subtypes, which are the HPV16, 18, 58, 33, and 52 subtypes, respectively. There was no significant relationship between multiple HPV infections and cervical cancer stage, lesion size, pathological tissue type, tissue differentiation degree/vascular cancer thrombus, and lymph node metastasis, and there was no significant difference in the results between the groups. In summary, multiple types of HPV infection in the cervix are common. We found that multiple infections, mainly HPV16, are closely related to cervical cancer. For the HPV16, 18, 58, 33, and 52 subtypes of infection, especially for patients younger than 40 years old and older than 70 years old, priority should be given to prevention and treatment. The relationship between multiple HPV infections and the progression and prognosis of cervical carcinoma requires further research, which could better guide cancer prevention and treatment. |
format | Online Article Text |
id | pubmed-10416435 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104164352023-08-12 The correlation between multiple HPV infections and the occurrence, development, and prognosis of cervical cancer Na, Jing Li, Ya Wang, Jun Wang, Xinyou Lu, JunLing Han, Shichao Front Microbiol Microbiology Cervical carcinoma is the fourth female malignant tumor in the world, and the persistent infection of high-risk human papillomavirus (HPV) is recognized as the most common cause. This article studies the correlation between multiple HPV infections and the occurrence, development, and prognosis of cervical cancer in order to provide more references for clinical diagnosis and treatment. We conducted a retrospective analysis of the clinical data of 400 cervical carcinoma patients admitted to our hospital from 2015 to 2023. The collected patient data include age, HPV infection status, tumor size and morphology, local infiltration depth, diagnostic staging, surgical approach, vascular cancer thrombus status, lymph node status, and postoperative HPV follow-up status. We use SPSS statistical software for data analysis. Our research shows that the high-risk age group for cervical carcinoma is concentrated between 41 and 60 years old, which is basically consistent with the age range of the high incidence of HPV infection. In the statistics for HPV infection types, ~67.7% of patients are single HPV-infected, 25.29% are double infected, and 7.00% are infected with three or more types of HPV. Among the multiple HPV infections, most of the patients are younger than 40 years old and older than 70 years old, with double infection accounting for the majority. The top five HPV subtypes with high detection rates belong to high-risk subtypes, which are the HPV16, 18, 58, 33, and 52 subtypes, respectively. There was no significant relationship between multiple HPV infections and cervical cancer stage, lesion size, pathological tissue type, tissue differentiation degree/vascular cancer thrombus, and lymph node metastasis, and there was no significant difference in the results between the groups. In summary, multiple types of HPV infection in the cervix are common. We found that multiple infections, mainly HPV16, are closely related to cervical cancer. For the HPV16, 18, 58, 33, and 52 subtypes of infection, especially for patients younger than 40 years old and older than 70 years old, priority should be given to prevention and treatment. The relationship between multiple HPV infections and the progression and prognosis of cervical carcinoma requires further research, which could better guide cancer prevention and treatment. Frontiers Media S.A. 2023-07-28 /pmc/articles/PMC10416435/ /pubmed/37577444 http://dx.doi.org/10.3389/fmicb.2023.1220522 Text en Copyright © 2023 Na, Li, Wang, Wang, Lu and Han. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Na, Jing Li, Ya Wang, Jun Wang, Xinyou Lu, JunLing Han, Shichao The correlation between multiple HPV infections and the occurrence, development, and prognosis of cervical cancer |
title | The correlation between multiple HPV infections and the occurrence, development, and prognosis of cervical cancer |
title_full | The correlation between multiple HPV infections and the occurrence, development, and prognosis of cervical cancer |
title_fullStr | The correlation between multiple HPV infections and the occurrence, development, and prognosis of cervical cancer |
title_full_unstemmed | The correlation between multiple HPV infections and the occurrence, development, and prognosis of cervical cancer |
title_short | The correlation between multiple HPV infections and the occurrence, development, and prognosis of cervical cancer |
title_sort | correlation between multiple hpv infections and the occurrence, development, and prognosis of cervical cancer |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416435/ https://www.ncbi.nlm.nih.gov/pubmed/37577444 http://dx.doi.org/10.3389/fmicb.2023.1220522 |
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