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Association between metabolic healthy obesity and female infertility: the national health and nutrition examination survey, 2013–2020
BACKGROUND: Obesity has been confirmed to be associated with infertility. However, the association between metabolically healthy obesity (MHO), a subset of obesity with no metabolic abnormalities, and female infertility has not yet been investigated. This study aimed to examine the association betwe...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416469/ https://www.ncbi.nlm.nih.gov/pubmed/37563562 http://dx.doi.org/10.1186/s12889-023-16397-x |
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author | Tang, Jing Xu, Yun Wang, Zhaorui Ji, Xiaohui Qiu, Qi Mai, Zhuoyao Huang, Jia Ouyang, Nengyong Chen, Hui |
author_facet | Tang, Jing Xu, Yun Wang, Zhaorui Ji, Xiaohui Qiu, Qi Mai, Zhuoyao Huang, Jia Ouyang, Nengyong Chen, Hui |
author_sort | Tang, Jing |
collection | PubMed |
description | BACKGROUND: Obesity has been confirmed to be associated with infertility. However, the association between metabolically healthy obesity (MHO), a subset of obesity with no metabolic abnormalities, and female infertility has not yet been investigated. This study aimed to examine the association between MHO and the risk of female infertility among United States. METHODS: This study utilized a cross-sectional design and included 3542 women aged 20–45 years who were selected from the National Health and Nutrition Examination Survey (NHANES) 2013–2020 database. The association between MHO and the risk of infertility was evaluated using risk factor–adjusted logistic regression models. RESULTS: Higher BMI and WC were associated with increased infertility risk after adjusting for potential confounding factors (OR (95% CI): 1.04(1.02, 1.06), P = 0.001; OR (95% CI): 1.02 (1.01, 1.03), P < 0.001; respectively). After cross-classifying by metabolic health and obesity according to BMI and WC categories, individuals with MHO had a higher risk of infertility than those with MHN (OR (95% CI): 1.75(0.88, 3.50) for BMI criteria; OR (95% CI): 2.01(1.03, 3.95) for WC criteria). A positive linear relationship was observed between BMI/WC and infertility risk among metabolically healthy women (P(non−linearity)=0.306, 0.170; respectively). CONCLUSIONS: MHO was associated with an increased risk of infertility among reproductive-aged women in the US. Obesity itself, regardless of metabolic health status, was associated with a higher infertility risk. Our results support implementing lifestyle changes aimed at achieving and maintaining a healthy body weight in all individuals, even those who are metabolically healthy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-023-16397-x. |
format | Online Article Text |
id | pubmed-10416469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-104164692023-08-12 Association between metabolic healthy obesity and female infertility: the national health and nutrition examination survey, 2013–2020 Tang, Jing Xu, Yun Wang, Zhaorui Ji, Xiaohui Qiu, Qi Mai, Zhuoyao Huang, Jia Ouyang, Nengyong Chen, Hui BMC Public Health Research BACKGROUND: Obesity has been confirmed to be associated with infertility. However, the association between metabolically healthy obesity (MHO), a subset of obesity with no metabolic abnormalities, and female infertility has not yet been investigated. This study aimed to examine the association between MHO and the risk of female infertility among United States. METHODS: This study utilized a cross-sectional design and included 3542 women aged 20–45 years who were selected from the National Health and Nutrition Examination Survey (NHANES) 2013–2020 database. The association between MHO and the risk of infertility was evaluated using risk factor–adjusted logistic regression models. RESULTS: Higher BMI and WC were associated with increased infertility risk after adjusting for potential confounding factors (OR (95% CI): 1.04(1.02, 1.06), P = 0.001; OR (95% CI): 1.02 (1.01, 1.03), P < 0.001; respectively). After cross-classifying by metabolic health and obesity according to BMI and WC categories, individuals with MHO had a higher risk of infertility than those with MHN (OR (95% CI): 1.75(0.88, 3.50) for BMI criteria; OR (95% CI): 2.01(1.03, 3.95) for WC criteria). A positive linear relationship was observed between BMI/WC and infertility risk among metabolically healthy women (P(non−linearity)=0.306, 0.170; respectively). CONCLUSIONS: MHO was associated with an increased risk of infertility among reproductive-aged women in the US. Obesity itself, regardless of metabolic health status, was associated with a higher infertility risk. Our results support implementing lifestyle changes aimed at achieving and maintaining a healthy body weight in all individuals, even those who are metabolically healthy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-023-16397-x. BioMed Central 2023-08-10 /pmc/articles/PMC10416469/ /pubmed/37563562 http://dx.doi.org/10.1186/s12889-023-16397-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Tang, Jing Xu, Yun Wang, Zhaorui Ji, Xiaohui Qiu, Qi Mai, Zhuoyao Huang, Jia Ouyang, Nengyong Chen, Hui Association between metabolic healthy obesity and female infertility: the national health and nutrition examination survey, 2013–2020 |
title | Association between metabolic healthy obesity and female infertility: the national health and nutrition examination survey, 2013–2020 |
title_full | Association between metabolic healthy obesity and female infertility: the national health and nutrition examination survey, 2013–2020 |
title_fullStr | Association between metabolic healthy obesity and female infertility: the national health and nutrition examination survey, 2013–2020 |
title_full_unstemmed | Association between metabolic healthy obesity and female infertility: the national health and nutrition examination survey, 2013–2020 |
title_short | Association between metabolic healthy obesity and female infertility: the national health and nutrition examination survey, 2013–2020 |
title_sort | association between metabolic healthy obesity and female infertility: the national health and nutrition examination survey, 2013–2020 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416469/ https://www.ncbi.nlm.nih.gov/pubmed/37563562 http://dx.doi.org/10.1186/s12889-023-16397-x |
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