Cargando…

Facile and eco-friendly fabrication of biocompatible hydrogel containing CuS@Ser NPs with mechanical flexibility and photothermal antibacterial activity to promote infected wound healing

Bacterial infections can significantly impede wound healing and pose a serious threat to the patient’s life. The excessive use of antibiotics to combat bacterial infections has led to the emergence of multi-drug-resistant bacteria. Therefore, there is a pressing need for alternative approaches, such...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Ye, Xie, Bingqing, Jiang, Min, Yuan, Lingling, Jiang, Xueyu, Li, Silei, Cai, Rui, Chen, Junliang, Jiang, Xia, He, Yun, Tao, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416498/
https://www.ncbi.nlm.nih.gov/pubmed/37563585
http://dx.doi.org/10.1186/s12951-023-02035-6
_version_ 1785087792567549952
author Guo, Ye
Xie, Bingqing
Jiang, Min
Yuan, Lingling
Jiang, Xueyu
Li, Silei
Cai, Rui
Chen, Junliang
Jiang, Xia
He, Yun
Tao, Gang
author_facet Guo, Ye
Xie, Bingqing
Jiang, Min
Yuan, Lingling
Jiang, Xueyu
Li, Silei
Cai, Rui
Chen, Junliang
Jiang, Xia
He, Yun
Tao, Gang
author_sort Guo, Ye
collection PubMed
description Bacterial infections can significantly impede wound healing and pose a serious threat to the patient’s life. The excessive use of antibiotics to combat bacterial infections has led to the emergence of multi-drug-resistant bacteria. Therefore, there is a pressing need for alternative approaches, such as photothermal therapy (PTT), to address this issue. In this study, for the first time, CuS NPs with photothermal properties were synthesized using sericin as a biological template, named CuS@Ser NPs. This method is simple, green, and does not produce toxic and harmful by-products. These nanoparticles were incorporated into a mixture (XK) of xanthan gum and konjac glucomannan (KGM) to obtain XK/CuS NPs composite hydrogel, which could overcome the limitations of current wound dressings. The composite hydrogel exhibited excellent mechanical flexibility, photothermal response, and biocompatibility. It also demonstrated potent antibacterial properties against both Gram-positive and negative bacteria via antibacterial experiments and accelerated wound healing in animal models. Additionally, it is proved that the hydrogel promoted tissue regeneration by stimulating collagen deposition, angiogenesis, and reducing inflammation. In summary, the XK/CuS NPs composite hydrogel presents a promising alternative for the clinical management of infected wounds, offering a new approach to promote infected wound healing. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-023-02035-6.
format Online
Article
Text
id pubmed-10416498
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-104164982023-08-12 Facile and eco-friendly fabrication of biocompatible hydrogel containing CuS@Ser NPs with mechanical flexibility and photothermal antibacterial activity to promote infected wound healing Guo, Ye Xie, Bingqing Jiang, Min Yuan, Lingling Jiang, Xueyu Li, Silei Cai, Rui Chen, Junliang Jiang, Xia He, Yun Tao, Gang J Nanobiotechnology Research Bacterial infections can significantly impede wound healing and pose a serious threat to the patient’s life. The excessive use of antibiotics to combat bacterial infections has led to the emergence of multi-drug-resistant bacteria. Therefore, there is a pressing need for alternative approaches, such as photothermal therapy (PTT), to address this issue. In this study, for the first time, CuS NPs with photothermal properties were synthesized using sericin as a biological template, named CuS@Ser NPs. This method is simple, green, and does not produce toxic and harmful by-products. These nanoparticles were incorporated into a mixture (XK) of xanthan gum and konjac glucomannan (KGM) to obtain XK/CuS NPs composite hydrogel, which could overcome the limitations of current wound dressings. The composite hydrogel exhibited excellent mechanical flexibility, photothermal response, and biocompatibility. It also demonstrated potent antibacterial properties against both Gram-positive and negative bacteria via antibacterial experiments and accelerated wound healing in animal models. Additionally, it is proved that the hydrogel promoted tissue regeneration by stimulating collagen deposition, angiogenesis, and reducing inflammation. In summary, the XK/CuS NPs composite hydrogel presents a promising alternative for the clinical management of infected wounds, offering a new approach to promote infected wound healing. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-023-02035-6. BioMed Central 2023-08-10 /pmc/articles/PMC10416498/ /pubmed/37563585 http://dx.doi.org/10.1186/s12951-023-02035-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Guo, Ye
Xie, Bingqing
Jiang, Min
Yuan, Lingling
Jiang, Xueyu
Li, Silei
Cai, Rui
Chen, Junliang
Jiang, Xia
He, Yun
Tao, Gang
Facile and eco-friendly fabrication of biocompatible hydrogel containing CuS@Ser NPs with mechanical flexibility and photothermal antibacterial activity to promote infected wound healing
title Facile and eco-friendly fabrication of biocompatible hydrogel containing CuS@Ser NPs with mechanical flexibility and photothermal antibacterial activity to promote infected wound healing
title_full Facile and eco-friendly fabrication of biocompatible hydrogel containing CuS@Ser NPs with mechanical flexibility and photothermal antibacterial activity to promote infected wound healing
title_fullStr Facile and eco-friendly fabrication of biocompatible hydrogel containing CuS@Ser NPs with mechanical flexibility and photothermal antibacterial activity to promote infected wound healing
title_full_unstemmed Facile and eco-friendly fabrication of biocompatible hydrogel containing CuS@Ser NPs with mechanical flexibility and photothermal antibacterial activity to promote infected wound healing
title_short Facile and eco-friendly fabrication of biocompatible hydrogel containing CuS@Ser NPs with mechanical flexibility and photothermal antibacterial activity to promote infected wound healing
title_sort facile and eco-friendly fabrication of biocompatible hydrogel containing cus@ser nps with mechanical flexibility and photothermal antibacterial activity to promote infected wound healing
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416498/
https://www.ncbi.nlm.nih.gov/pubmed/37563585
http://dx.doi.org/10.1186/s12951-023-02035-6
work_keys_str_mv AT guoye facileandecofriendlyfabricationofbiocompatiblehydrogelcontainingcussernpswithmechanicalflexibilityandphotothermalantibacterialactivitytopromoteinfectedwoundhealing
AT xiebingqing facileandecofriendlyfabricationofbiocompatiblehydrogelcontainingcussernpswithmechanicalflexibilityandphotothermalantibacterialactivitytopromoteinfectedwoundhealing
AT jiangmin facileandecofriendlyfabricationofbiocompatiblehydrogelcontainingcussernpswithmechanicalflexibilityandphotothermalantibacterialactivitytopromoteinfectedwoundhealing
AT yuanlingling facileandecofriendlyfabricationofbiocompatiblehydrogelcontainingcussernpswithmechanicalflexibilityandphotothermalantibacterialactivitytopromoteinfectedwoundhealing
AT jiangxueyu facileandecofriendlyfabricationofbiocompatiblehydrogelcontainingcussernpswithmechanicalflexibilityandphotothermalantibacterialactivitytopromoteinfectedwoundhealing
AT lisilei facileandecofriendlyfabricationofbiocompatiblehydrogelcontainingcussernpswithmechanicalflexibilityandphotothermalantibacterialactivitytopromoteinfectedwoundhealing
AT cairui facileandecofriendlyfabricationofbiocompatiblehydrogelcontainingcussernpswithmechanicalflexibilityandphotothermalantibacterialactivitytopromoteinfectedwoundhealing
AT chenjunliang facileandecofriendlyfabricationofbiocompatiblehydrogelcontainingcussernpswithmechanicalflexibilityandphotothermalantibacterialactivitytopromoteinfectedwoundhealing
AT jiangxia facileandecofriendlyfabricationofbiocompatiblehydrogelcontainingcussernpswithmechanicalflexibilityandphotothermalantibacterialactivitytopromoteinfectedwoundhealing
AT heyun facileandecofriendlyfabricationofbiocompatiblehydrogelcontainingcussernpswithmechanicalflexibilityandphotothermalantibacterialactivitytopromoteinfectedwoundhealing
AT taogang facileandecofriendlyfabricationofbiocompatiblehydrogelcontainingcussernpswithmechanicalflexibilityandphotothermalantibacterialactivitytopromoteinfectedwoundhealing