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Nano drug delivery systems: a promising approach to scar prevention and treatment

Scar formation is a common physiological process that occurs after injury, but in some cases, pathological scars can develop, leading to serious physiological and psychological effects. Unfortunately, there are currently no effective means to intervene in scar formation, and the structural features...

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Autores principales: Ding, Jia-Ying, Sun, Lu, Zhu, Zhi-Heng, Wu, Xi-Chen, Xu, Xiao-Ling, Xiang, Yan-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416511/
https://www.ncbi.nlm.nih.gov/pubmed/37568194
http://dx.doi.org/10.1186/s12951-023-02037-4
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author Ding, Jia-Ying
Sun, Lu
Zhu, Zhi-Heng
Wu, Xi-Chen
Xu, Xiao-Ling
Xiang, Yan-Wei
author_facet Ding, Jia-Ying
Sun, Lu
Zhu, Zhi-Heng
Wu, Xi-Chen
Xu, Xiao-Ling
Xiang, Yan-Wei
author_sort Ding, Jia-Ying
collection PubMed
description Scar formation is a common physiological process that occurs after injury, but in some cases, pathological scars can develop, leading to serious physiological and psychological effects. Unfortunately, there are currently no effective means to intervene in scar formation, and the structural features of scars and their unclear mechanisms make prevention and treatment even more challenging. However, the emergence of nanotechnology in drug delivery systems offers a promising avenue for the prevention and treatment of scars. Nanomaterials possess unique properties that make them well suited for addressing issues related to transdermal drug delivery, drug solubility, and controlled release. Herein, we summarize the recent progress made in the use of nanotechnology for the prevention and treatment of scars. We examine the mechanisms involved and the advantages offered by various types of nanomaterials. We also highlight the outstanding challenges and questions that need to be addressed to maximize the potential of nanotechnology in scar intervention. Overall, with further development, nanotechnology could significantly improve the prevention and treatment of pathological scars, providing a brighter outlook for those affected by this condition.
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spelling pubmed-104165112023-08-12 Nano drug delivery systems: a promising approach to scar prevention and treatment Ding, Jia-Ying Sun, Lu Zhu, Zhi-Heng Wu, Xi-Chen Xu, Xiao-Ling Xiang, Yan-Wei J Nanobiotechnology Review Scar formation is a common physiological process that occurs after injury, but in some cases, pathological scars can develop, leading to serious physiological and psychological effects. Unfortunately, there are currently no effective means to intervene in scar formation, and the structural features of scars and their unclear mechanisms make prevention and treatment even more challenging. However, the emergence of nanotechnology in drug delivery systems offers a promising avenue for the prevention and treatment of scars. Nanomaterials possess unique properties that make them well suited for addressing issues related to transdermal drug delivery, drug solubility, and controlled release. Herein, we summarize the recent progress made in the use of nanotechnology for the prevention and treatment of scars. We examine the mechanisms involved and the advantages offered by various types of nanomaterials. We also highlight the outstanding challenges and questions that need to be addressed to maximize the potential of nanotechnology in scar intervention. Overall, with further development, nanotechnology could significantly improve the prevention and treatment of pathological scars, providing a brighter outlook for those affected by this condition. BioMed Central 2023-08-11 /pmc/articles/PMC10416511/ /pubmed/37568194 http://dx.doi.org/10.1186/s12951-023-02037-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ding, Jia-Ying
Sun, Lu
Zhu, Zhi-Heng
Wu, Xi-Chen
Xu, Xiao-Ling
Xiang, Yan-Wei
Nano drug delivery systems: a promising approach to scar prevention and treatment
title Nano drug delivery systems: a promising approach to scar prevention and treatment
title_full Nano drug delivery systems: a promising approach to scar prevention and treatment
title_fullStr Nano drug delivery systems: a promising approach to scar prevention and treatment
title_full_unstemmed Nano drug delivery systems: a promising approach to scar prevention and treatment
title_short Nano drug delivery systems: a promising approach to scar prevention and treatment
title_sort nano drug delivery systems: a promising approach to scar prevention and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416511/
https://www.ncbi.nlm.nih.gov/pubmed/37568194
http://dx.doi.org/10.1186/s12951-023-02037-4
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