Syk Inhibition Reprograms Tumor-Associated Macrophages and Overcomes Gemcitabine-Induced Immunosuppression in Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is an insidious disease with a low 5-year survival rate. PDAC is characterized by infiltration of abundant tumor-associated macrophages (TAM), which promote immune tolerance and immunotherapeutic resistance. Here we report that macrophage spleen tyrosine kinas...

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Detalles Bibliográficos
Autores principales: Rohila, Deepak, Park, In Hwan, Pham, Timothy V., Weitz, Jonathan, Hurtado de Mendoza, Tatiana, Madheswaran, Suresh, Ishfaq, Mehreen, Beaman, Cooper, Tapia, Elisabette, Sun, Siming, Patel, Jay, Tamayo, Pablo, Lowy, Andrew M., Joshi, Shweta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Cancer Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416758/
https://www.ncbi.nlm.nih.gov/pubmed/37306759
http://dx.doi.org/10.1158/0008-5472.CAN-22-3645

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