Antioxidant Nanoparticles Restore Cisplatin-Induced Male Fertility Defects by Promoting MDC1-53bp1-Associated Non-Homologous DNA Repair Mechanism and Sperm Intracellular Calcium Influx

INTRODUCTION: Cisplatin, a commonly used anticancer compound, exhibits severe off-target organ toxicity. Due to its wide application in cancer treatment, the reduction of its damage to normal tissue is an imminent clinical need. Cisplatin-induced testicular oxidative stress and damage lead to male s...

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Detalles Bibliográficos
Autores principales: Wei, Yu-Syuan, Chen, Yu-Liang, Li, Wei-Yun, Yang, Ya-Yi, Lin, Sung-Jan, Wu, Ching-Ho, Yang, Jiue-In, Wang, Tse-En, Yu, Jiashing, Tsai, Pei-Shiue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416785/
https://www.ncbi.nlm.nih.gov/pubmed/37576465
http://dx.doi.org/10.2147/IJN.S408623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416785/
https://www.ncbi.nlm.nih.gov/pubmed/37576465
http://dx.doi.org/10.2147/IJN.S408623

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