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Skin Involvement by Hematological Neoplasms with Blastic Morphology: Lymphoblastic Lymphoma, Blastoid Variant of Mantle Cell Lymphoma and Differential Diagnoses

SIMPLE SUMMARY: Pathologists working with skin biopsies of different hematological malignancies via blastic morphology need to consider a broad spectrum of diseases that, despite similar blastic features, have different outcomes and require distinct therapeutic strategies. Therefore, a precise and p...

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Autores principales: Zanelli, Magda, Sanguedolce, Francesca, Zizzo, Maurizio, Fragliasso, Valentina, Broggi, Giuseppe, Palicelli, Andrea, Loscocco, Giuseppe Gaetano, Cresta, Camilla, Caprera, Cecilia, Corsi, Matteo, Martino, Giovanni, Bisagni, Alessandra, Marchetti, Marialisa, Koufopoulos, Nektarios, Parente, Paola, Caltabiano, Rosario, Ascani, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416851/
https://www.ncbi.nlm.nih.gov/pubmed/37568745
http://dx.doi.org/10.3390/cancers15153928
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author Zanelli, Magda
Sanguedolce, Francesca
Zizzo, Maurizio
Fragliasso, Valentina
Broggi, Giuseppe
Palicelli, Andrea
Loscocco, Giuseppe Gaetano
Cresta, Camilla
Caprera, Cecilia
Corsi, Matteo
Martino, Giovanni
Bisagni, Alessandra
Marchetti, Marialisa
Koufopoulos, Nektarios
Parente, Paola
Caltabiano, Rosario
Ascani, Stefano
author_facet Zanelli, Magda
Sanguedolce, Francesca
Zizzo, Maurizio
Fragliasso, Valentina
Broggi, Giuseppe
Palicelli, Andrea
Loscocco, Giuseppe Gaetano
Cresta, Camilla
Caprera, Cecilia
Corsi, Matteo
Martino, Giovanni
Bisagni, Alessandra
Marchetti, Marialisa
Koufopoulos, Nektarios
Parente, Paola
Caltabiano, Rosario
Ascani, Stefano
author_sort Zanelli, Magda
collection PubMed
description SIMPLE SUMMARY: Pathologists working with skin biopsies of different hematological malignancies via blastic morphology need to consider a broad spectrum of diseases that, despite similar blastic features, have different outcomes and require distinct therapeutic strategies. Therefore, a precise and prompt diagnosis is critical for patient management. The aim of our paper is to discuss, in detail, the clinical and pathological features of lymphoblastic lymphoma of B- or T-cell origin and mantle cell lymphoma, in particular its aggressive blastoid variant. Although mantle cell lymphoma rarely involves the skin, its blastoid variant is commonly encountered in cutaneous infiltrates, possibly due to the increased tendency of aggressive subtypes for skin involvement. When aggressive lymphomas are detected at cutaneous sites, a complete systemic work-up is critical. Besides blastoid mantle cell lymphoma and lymphoblastic lymphoma, other hematological malignancies with blastic characteristics and skin involvement are discussed. ABSTRACT: Hematological neoplasms sharing a blastic morphology may involve the skin. The skin may be either the primary site of occurrence of hematological malignancies with blastic features or cutaneous lesions are the first manifestation of an underlying systemic malignancy. The assessment of skin biopsies of hematological neoplasms with blastic features poses diagnostic problems and requires expert hematopathologists considering a wide range of differential diagnoses. The precise diagnosis of diseases sharing blastic features but with different outcomes and requiring distinct therapies is essential for patient management. The present paper mainly focuses on cutaneous involvement of the blastoid variant of mantle cell lymphoma and lymphoblastic lymphoma of B-cell or T-cell origin. The relevant literature has been reviewed and the clinical aspects, pathological features, prognosis, and therapy of both blastoid mantle cell lymphoma and lymphoblastic lymphoma involving the skin are discussed. A focus on other hematological entities with blastic features, which may involve the skin, to be taken into consideration in differential diagnosis is also given.
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spelling pubmed-104168512023-08-12 Skin Involvement by Hematological Neoplasms with Blastic Morphology: Lymphoblastic Lymphoma, Blastoid Variant of Mantle Cell Lymphoma and Differential Diagnoses Zanelli, Magda Sanguedolce, Francesca Zizzo, Maurizio Fragliasso, Valentina Broggi, Giuseppe Palicelli, Andrea Loscocco, Giuseppe Gaetano Cresta, Camilla Caprera, Cecilia Corsi, Matteo Martino, Giovanni Bisagni, Alessandra Marchetti, Marialisa Koufopoulos, Nektarios Parente, Paola Caltabiano, Rosario Ascani, Stefano Cancers (Basel) Review SIMPLE SUMMARY: Pathologists working with skin biopsies of different hematological malignancies via blastic morphology need to consider a broad spectrum of diseases that, despite similar blastic features, have different outcomes and require distinct therapeutic strategies. Therefore, a precise and prompt diagnosis is critical for patient management. The aim of our paper is to discuss, in detail, the clinical and pathological features of lymphoblastic lymphoma of B- or T-cell origin and mantle cell lymphoma, in particular its aggressive blastoid variant. Although mantle cell lymphoma rarely involves the skin, its blastoid variant is commonly encountered in cutaneous infiltrates, possibly due to the increased tendency of aggressive subtypes for skin involvement. When aggressive lymphomas are detected at cutaneous sites, a complete systemic work-up is critical. Besides blastoid mantle cell lymphoma and lymphoblastic lymphoma, other hematological malignancies with blastic characteristics and skin involvement are discussed. ABSTRACT: Hematological neoplasms sharing a blastic morphology may involve the skin. The skin may be either the primary site of occurrence of hematological malignancies with blastic features or cutaneous lesions are the first manifestation of an underlying systemic malignancy. The assessment of skin biopsies of hematological neoplasms with blastic features poses diagnostic problems and requires expert hematopathologists considering a wide range of differential diagnoses. The precise diagnosis of diseases sharing blastic features but with different outcomes and requiring distinct therapies is essential for patient management. The present paper mainly focuses on cutaneous involvement of the blastoid variant of mantle cell lymphoma and lymphoblastic lymphoma of B-cell or T-cell origin. The relevant literature has been reviewed and the clinical aspects, pathological features, prognosis, and therapy of both blastoid mantle cell lymphoma and lymphoblastic lymphoma involving the skin are discussed. A focus on other hematological entities with blastic features, which may involve the skin, to be taken into consideration in differential diagnosis is also given. MDPI 2023-08-02 /pmc/articles/PMC10416851/ /pubmed/37568745 http://dx.doi.org/10.3390/cancers15153928 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zanelli, Magda
Sanguedolce, Francesca
Zizzo, Maurizio
Fragliasso, Valentina
Broggi, Giuseppe
Palicelli, Andrea
Loscocco, Giuseppe Gaetano
Cresta, Camilla
Caprera, Cecilia
Corsi, Matteo
Martino, Giovanni
Bisagni, Alessandra
Marchetti, Marialisa
Koufopoulos, Nektarios
Parente, Paola
Caltabiano, Rosario
Ascani, Stefano
Skin Involvement by Hematological Neoplasms with Blastic Morphology: Lymphoblastic Lymphoma, Blastoid Variant of Mantle Cell Lymphoma and Differential Diagnoses
title Skin Involvement by Hematological Neoplasms with Blastic Morphology: Lymphoblastic Lymphoma, Blastoid Variant of Mantle Cell Lymphoma and Differential Diagnoses
title_full Skin Involvement by Hematological Neoplasms with Blastic Morphology: Lymphoblastic Lymphoma, Blastoid Variant of Mantle Cell Lymphoma and Differential Diagnoses
title_fullStr Skin Involvement by Hematological Neoplasms with Blastic Morphology: Lymphoblastic Lymphoma, Blastoid Variant of Mantle Cell Lymphoma and Differential Diagnoses
title_full_unstemmed Skin Involvement by Hematological Neoplasms with Blastic Morphology: Lymphoblastic Lymphoma, Blastoid Variant of Mantle Cell Lymphoma and Differential Diagnoses
title_short Skin Involvement by Hematological Neoplasms with Blastic Morphology: Lymphoblastic Lymphoma, Blastoid Variant of Mantle Cell Lymphoma and Differential Diagnoses
title_sort skin involvement by hematological neoplasms with blastic morphology: lymphoblastic lymphoma, blastoid variant of mantle cell lymphoma and differential diagnoses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416851/
https://www.ncbi.nlm.nih.gov/pubmed/37568745
http://dx.doi.org/10.3390/cancers15153928
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