Current and Future Landscape in Genetic Therapies for Leber Hereditary Optic Neuropathy

Leber hereditary optic neuropathy (LHON) is the most common primary mitochondrial genetic disease that causes blindness in young adults. Over 50 inherited mitochondrial DNA (mtDNA) variations are associated with LHON; however, more than 95% of cases are caused by one of three missense variations (m....

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Detalles Bibliográficos
Autores principales: Shamsnajafabadi, Hoda, MacLaren, Robert E., Cehajic-Kapetanovic, Jasmina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416882/
https://www.ncbi.nlm.nih.gov/pubmed/37566092
http://dx.doi.org/10.3390/cells12152013

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