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Prognosis Predictive Markers in Patients with Chronic Obstructive Pulmonary Disease and COVID-19

Some studies have reported that chronic respiratory illnesses in patients with COVID-19 result in an increase in hospitalization and death rates, while other studies reported to the contrary. The present research aims to determine if a predictive model (developed by combing different clinical, imagi...

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Autores principales: Motoc, Nicoleta Ștefania, Făgărășan, Iulia, Urda-Cîmpean, Andrada Elena, Todea, Doina Adina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416888/
https://www.ncbi.nlm.nih.gov/pubmed/37568963
http://dx.doi.org/10.3390/diagnostics13152597
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author Motoc, Nicoleta Ștefania
Făgărășan, Iulia
Urda-Cîmpean, Andrada Elena
Todea, Doina Adina
author_facet Motoc, Nicoleta Ștefania
Făgărășan, Iulia
Urda-Cîmpean, Andrada Elena
Todea, Doina Adina
author_sort Motoc, Nicoleta Ștefania
collection PubMed
description Some studies have reported that chronic respiratory illnesses in patients with COVID-19 result in an increase in hospitalization and death rates, while other studies reported to the contrary. The present research aims to determine if a predictive model (developed by combing different clinical, imaging, or blood markers) could be established for patients with both chronic obstructive pulmonary disease (COPD) and COVID-19, in order to be able to foresee the outcomes of these patients. A prospective observational cohort of 165 patients with both diseases was analyzed in terms of clinical characteristics, blood tests, and chest computed tomography results. The beta-coefficients from the logistic regression were used to create a score based on the significant identified markers for poor outcomes (transfers to an intensive care unit (ICU) for mechanical ventilation, or death). The severity of COVID-19, renal failure, diabetes, smoking status (current or previous), the requirement for oxygen therapy upon admission, high lactate dehydrogenase (LDH) and C-reactive protein level (CRP readings), and low eosinophil and lymphocyte counts were all identified as being indicators of a poor prognosis. Higher mortality was linked to the occurrence of renal failure, the number of affected lobes, the need for oxygen therapy upon hospital admission, high LDH, and low lymphocyte levels. Patients had an 86.4% chance of dying if their mortality scores were −2.80 or lower, based on the predictive model. The factors that were linked to a poor prognosis in patients who had both COPD and COVID-19 were the same as those that were linked to a poor prognosis in patients who had only COVID-19.
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spelling pubmed-104168882023-08-12 Prognosis Predictive Markers in Patients with Chronic Obstructive Pulmonary Disease and COVID-19 Motoc, Nicoleta Ștefania Făgărășan, Iulia Urda-Cîmpean, Andrada Elena Todea, Doina Adina Diagnostics (Basel) Article Some studies have reported that chronic respiratory illnesses in patients with COVID-19 result in an increase in hospitalization and death rates, while other studies reported to the contrary. The present research aims to determine if a predictive model (developed by combing different clinical, imaging, or blood markers) could be established for patients with both chronic obstructive pulmonary disease (COPD) and COVID-19, in order to be able to foresee the outcomes of these patients. A prospective observational cohort of 165 patients with both diseases was analyzed in terms of clinical characteristics, blood tests, and chest computed tomography results. The beta-coefficients from the logistic regression were used to create a score based on the significant identified markers for poor outcomes (transfers to an intensive care unit (ICU) for mechanical ventilation, or death). The severity of COVID-19, renal failure, diabetes, smoking status (current or previous), the requirement for oxygen therapy upon admission, high lactate dehydrogenase (LDH) and C-reactive protein level (CRP readings), and low eosinophil and lymphocyte counts were all identified as being indicators of a poor prognosis. Higher mortality was linked to the occurrence of renal failure, the number of affected lobes, the need for oxygen therapy upon hospital admission, high LDH, and low lymphocyte levels. Patients had an 86.4% chance of dying if their mortality scores were −2.80 or lower, based on the predictive model. The factors that were linked to a poor prognosis in patients who had both COPD and COVID-19 were the same as those that were linked to a poor prognosis in patients who had only COVID-19. MDPI 2023-08-04 /pmc/articles/PMC10416888/ /pubmed/37568963 http://dx.doi.org/10.3390/diagnostics13152597 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Motoc, Nicoleta Ștefania
Făgărășan, Iulia
Urda-Cîmpean, Andrada Elena
Todea, Doina Adina
Prognosis Predictive Markers in Patients with Chronic Obstructive Pulmonary Disease and COVID-19
title Prognosis Predictive Markers in Patients with Chronic Obstructive Pulmonary Disease and COVID-19
title_full Prognosis Predictive Markers in Patients with Chronic Obstructive Pulmonary Disease and COVID-19
title_fullStr Prognosis Predictive Markers in Patients with Chronic Obstructive Pulmonary Disease and COVID-19
title_full_unstemmed Prognosis Predictive Markers in Patients with Chronic Obstructive Pulmonary Disease and COVID-19
title_short Prognosis Predictive Markers in Patients with Chronic Obstructive Pulmonary Disease and COVID-19
title_sort prognosis predictive markers in patients with chronic obstructive pulmonary disease and covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416888/
https://www.ncbi.nlm.nih.gov/pubmed/37568963
http://dx.doi.org/10.3390/diagnostics13152597
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