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Implication of mTOR Signaling in NSCLC: Mechanisms and Therapeutic Perspectives

Mechanistic target of the rapamycin (mTOR) signaling pathway represents a central cellular kinase that controls cell survival and metabolism. Increased mTOR activation, along with upregulation of respective upstream and downstream signaling components, have been established as oncogenic features in...

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Autores principales: Gargalionis, Antonios N., Papavassiliou, Kostas A., Papavassiliou, Athanasios G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416991/
https://www.ncbi.nlm.nih.gov/pubmed/37566093
http://dx.doi.org/10.3390/cells12152014
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author Gargalionis, Antonios N.
Papavassiliou, Kostas A.
Papavassiliou, Athanasios G.
author_facet Gargalionis, Antonios N.
Papavassiliou, Kostas A.
Papavassiliou, Athanasios G.
author_sort Gargalionis, Antonios N.
collection PubMed
description Mechanistic target of the rapamycin (mTOR) signaling pathway represents a central cellular kinase that controls cell survival and metabolism. Increased mTOR activation, along with upregulation of respective upstream and downstream signaling components, have been established as oncogenic features in cancer cells in various tumor types. Nevertheless, mTOR pathway therapeutic targeting has been proven to be quite challenging in various clinical settings. Non-small cell lung cancer (NSCLC) is a frequent type of solid tumor in both genders, where aberrant regulation of the mTOR pathway contributes to the development of oncogenesis, apoptosis resistance, angiogenesis, cancer progression, and metastasis. In this context, the outcome of mTOR pathway targeting in clinical trials still demonstrates unsatisfactory results. Herewith, we discuss recent findings regarding the mechanisms and therapeutic targeting of mTOR signaling networks in NSCLC, as well as future perspectives for the efficient application of treatments against mTOR and related protein molecules.
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spelling pubmed-104169912023-08-12 Implication of mTOR Signaling in NSCLC: Mechanisms and Therapeutic Perspectives Gargalionis, Antonios N. Papavassiliou, Kostas A. Papavassiliou, Athanasios G. Cells Communication Mechanistic target of the rapamycin (mTOR) signaling pathway represents a central cellular kinase that controls cell survival and metabolism. Increased mTOR activation, along with upregulation of respective upstream and downstream signaling components, have been established as oncogenic features in cancer cells in various tumor types. Nevertheless, mTOR pathway therapeutic targeting has been proven to be quite challenging in various clinical settings. Non-small cell lung cancer (NSCLC) is a frequent type of solid tumor in both genders, where aberrant regulation of the mTOR pathway contributes to the development of oncogenesis, apoptosis resistance, angiogenesis, cancer progression, and metastasis. In this context, the outcome of mTOR pathway targeting in clinical trials still demonstrates unsatisfactory results. Herewith, we discuss recent findings regarding the mechanisms and therapeutic targeting of mTOR signaling networks in NSCLC, as well as future perspectives for the efficient application of treatments against mTOR and related protein molecules. MDPI 2023-08-07 /pmc/articles/PMC10416991/ /pubmed/37566093 http://dx.doi.org/10.3390/cells12152014 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Gargalionis, Antonios N.
Papavassiliou, Kostas A.
Papavassiliou, Athanasios G.
Implication of mTOR Signaling in NSCLC: Mechanisms and Therapeutic Perspectives
title Implication of mTOR Signaling in NSCLC: Mechanisms and Therapeutic Perspectives
title_full Implication of mTOR Signaling in NSCLC: Mechanisms and Therapeutic Perspectives
title_fullStr Implication of mTOR Signaling in NSCLC: Mechanisms and Therapeutic Perspectives
title_full_unstemmed Implication of mTOR Signaling in NSCLC: Mechanisms and Therapeutic Perspectives
title_short Implication of mTOR Signaling in NSCLC: Mechanisms and Therapeutic Perspectives
title_sort implication of mtor signaling in nsclc: mechanisms and therapeutic perspectives
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416991/
https://www.ncbi.nlm.nih.gov/pubmed/37566093
http://dx.doi.org/10.3390/cells12152014
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