The Efficacy of CB-103, a First-in-Class Transcriptional Notch Inhibitor, in Preclinical Models of Breast Cancer

SIMPLE SUMMARY: Notch signaling has been shown to mediate treatment resistance and support cancer stem cells (CSC) in luminal endocrine-resistant and triple negative breast cancers (TNBCs). The clinical development of GSIs, first-generation Notch inhibitors, has been hindered by a lack of Notch spec...

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Detalles Bibliográficos
Autores principales: Vigolo, Michele, Urech, Charlotte, Lamy, Sebastien, Monticone, Giulia, Zabaleta, Jovanny, Hossain, Fokhrul, Wyczechowska, Dorota, Del Valle, Luis, O’Regan, Ruth M., Miele, Lucio, Lehal, Rajwinder, Majumder, Samarpan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416998/
https://www.ncbi.nlm.nih.gov/pubmed/37568775
http://dx.doi.org/10.3390/cancers15153957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416998/
https://www.ncbi.nlm.nih.gov/pubmed/37568775
http://dx.doi.org/10.3390/cancers15153957

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