Cargando…
Pancreatic Intraductal Papillary Mucinous Neoplasms: A Narrative Review
INTRODUCTION: Intraductal papillary mucinous neoplasms (IPMNs) are the most frequent cystic pancreatic neoplasm. They derive from the main pancreatic duct or branch ducts. AIM: This narrative review aims to present and compare the current guidelines on the management of IPMNs. MATERIALS AND METHODS:...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Vilnius University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417013/ https://www.ncbi.nlm.nih.gov/pubmed/37575378 http://dx.doi.org/10.15388/Amed.2023.30.1.6 |
_version_ | 1785087918517256192 |
---|---|
author | Paramythiotis, Daniel Karlafti, Eleni Fotiadou, Georgia Charalampidou, Maria Karakatsanis, Anestis Ioannidis, Aristeidis Michalopoulos, Antonios |
author_facet | Paramythiotis, Daniel Karlafti, Eleni Fotiadou, Georgia Charalampidou, Maria Karakatsanis, Anestis Ioannidis, Aristeidis Michalopoulos, Antonios |
author_sort | Paramythiotis, Daniel |
collection | PubMed |
description | INTRODUCTION: Intraductal papillary mucinous neoplasms (IPMNs) are the most frequent cystic pancreatic neoplasm. They derive from the main pancreatic duct or branch ducts. AIM: This narrative review aims to present and compare the current guidelines on the management of IPMNs. MATERIALS AND METHODS: We reviewed the most important scientific literature on the management of IPMNs. DISCUSSION: The clinical presentation of IPMNs is usually nonspecific; common symptoms are abdominal pain, weight loss, and jaundice. There are no sex differences, and the incidence increases with age. It is considered a premalignant lesion associated with synchronous or metachronous carcinomas. Multifocal sites within the pancreas and the presence of solid components, like mural nodules, are predictive factors for developing malignancy. Magnetic resonance imaging (MRI) is the imaging technique of choice. However, computed tomography (CT) and endoscopic ultrasound (EUS) with fine-needle aspiration (FNA) can also contribute to the diagnosis. Resection is the optimal treatment for IPMNs that arise from the main duct, while several indications are suggested for the surgery on IPMNs of branch ducts. CONCLUSION: The decision on surgery is not always a simple task and should be based on high-risk features of the neoplasm. In any case, re-examination and follow-up are highly recommended. |
format | Online Article Text |
id | pubmed-10417013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Vilnius University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-104170132023-08-12 Pancreatic Intraductal Papillary Mucinous Neoplasms: A Narrative Review Paramythiotis, Daniel Karlafti, Eleni Fotiadou, Georgia Charalampidou, Maria Karakatsanis, Anestis Ioannidis, Aristeidis Michalopoulos, Antonios Acta Med Litu Review Papers INTRODUCTION: Intraductal papillary mucinous neoplasms (IPMNs) are the most frequent cystic pancreatic neoplasm. They derive from the main pancreatic duct or branch ducts. AIM: This narrative review aims to present and compare the current guidelines on the management of IPMNs. MATERIALS AND METHODS: We reviewed the most important scientific literature on the management of IPMNs. DISCUSSION: The clinical presentation of IPMNs is usually nonspecific; common symptoms are abdominal pain, weight loss, and jaundice. There are no sex differences, and the incidence increases with age. It is considered a premalignant lesion associated with synchronous or metachronous carcinomas. Multifocal sites within the pancreas and the presence of solid components, like mural nodules, are predictive factors for developing malignancy. Magnetic resonance imaging (MRI) is the imaging technique of choice. However, computed tomography (CT) and endoscopic ultrasound (EUS) with fine-needle aspiration (FNA) can also contribute to the diagnosis. Resection is the optimal treatment for IPMNs that arise from the main duct, while several indications are suggested for the surgery on IPMNs of branch ducts. CONCLUSION: The decision on surgery is not always a simple task and should be based on high-risk features of the neoplasm. In any case, re-examination and follow-up are highly recommended. Vilnius University Press 2023 2023-02-27 /pmc/articles/PMC10417013/ /pubmed/37575378 http://dx.doi.org/10.15388/Amed.2023.30.1.6 Text en Copyright © 2023 Daniel Paramythiotis, Eleni Karlafti, Georgia Fotiadou, Maria Charalampidou, Anestis Karakatsanis, Aristeidis Ioannidis, Antonios Michalopoulos. Published by Vilnius University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Papers Paramythiotis, Daniel Karlafti, Eleni Fotiadou, Georgia Charalampidou, Maria Karakatsanis, Anestis Ioannidis, Aristeidis Michalopoulos, Antonios Pancreatic Intraductal Papillary Mucinous Neoplasms: A Narrative Review |
title | Pancreatic Intraductal Papillary Mucinous Neoplasms: A Narrative Review |
title_full | Pancreatic Intraductal Papillary Mucinous Neoplasms: A Narrative Review |
title_fullStr | Pancreatic Intraductal Papillary Mucinous Neoplasms: A Narrative Review |
title_full_unstemmed | Pancreatic Intraductal Papillary Mucinous Neoplasms: A Narrative Review |
title_short | Pancreatic Intraductal Papillary Mucinous Neoplasms: A Narrative Review |
title_sort | pancreatic intraductal papillary mucinous neoplasms: a narrative review |
topic | Review Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417013/ https://www.ncbi.nlm.nih.gov/pubmed/37575378 http://dx.doi.org/10.15388/Amed.2023.30.1.6 |
work_keys_str_mv | AT paramythiotisdaniel pancreaticintraductalpapillarymucinousneoplasmsanarrativereview AT karlaftieleni pancreaticintraductalpapillarymucinousneoplasmsanarrativereview AT fotiadougeorgia pancreaticintraductalpapillarymucinousneoplasmsanarrativereview AT charalampidoumaria pancreaticintraductalpapillarymucinousneoplasmsanarrativereview AT karakatsanisanestis pancreaticintraductalpapillarymucinousneoplasmsanarrativereview AT ioannidisaristeidis pancreaticintraductalpapillarymucinousneoplasmsanarrativereview AT michalopoulosantonios pancreaticintraductalpapillarymucinousneoplasmsanarrativereview |