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Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins

The compounds of seminal plasma have great potential as biomarkers of male fertility and can be used as a diagnostic tool for types of azoospermia. Azoospermia occurs in approximately 1% of the male population, and for an effective therapy of this form of male infertility, it is important to disting...

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Autores principales: Ješeta, Michal, Pospíšilová, Anna, Mekiňová, Lenka, Franzová, Kateřina, Ventruba, Pavel, Lousová, Eva, Kempisty, Bartosz, Oždian, Tomáš, Žáková, Jana, Crha, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417070/
https://www.ncbi.nlm.nih.gov/pubmed/37568830
http://dx.doi.org/10.3390/diagnostics13152468
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author Ješeta, Michal
Pospíšilová, Anna
Mekiňová, Lenka
Franzová, Kateřina
Ventruba, Pavel
Lousová, Eva
Kempisty, Bartosz
Oždian, Tomáš
Žáková, Jana
Crha, Igor
author_facet Ješeta, Michal
Pospíšilová, Anna
Mekiňová, Lenka
Franzová, Kateřina
Ventruba, Pavel
Lousová, Eva
Kempisty, Bartosz
Oždian, Tomáš
Žáková, Jana
Crha, Igor
author_sort Ješeta, Michal
collection PubMed
description The compounds of seminal plasma have great potential as biomarkers of male fertility and can be used as a diagnostic tool for types of azoospermia. Azoospermia occurs in approximately 1% of the male population, and for an effective therapy of this form of male infertility, it is important to distinguish between obstructive and non-obstructive azoospermia. Proteins in seminal plasma can serve as biomarkers for diagnosing azoospermia. Considering the various types of obstructions, a combination of multiple proteins is advisable for diagnostic purposes. In this context, testicular and epididymal proteins are particularly significant, as they are specific to these tissues and typically absent in ejaculate during most obstructions. A combination of multiple biomarkers is more effective than the analysis of a single protein. This group of markers contains TEX101 and ECM1 proteins, combined detections of these two bring a diagnostic output with a high sensitivity and specificity. Similar results were observed for combined detection of TEX101 and SPAG1. The effective using of specific biomarkers from seminal plasma can significantly improve the existing approaches to diagnosis of the causes of male infertility.
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spelling pubmed-104170702023-08-12 Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins Ješeta, Michal Pospíšilová, Anna Mekiňová, Lenka Franzová, Kateřina Ventruba, Pavel Lousová, Eva Kempisty, Bartosz Oždian, Tomáš Žáková, Jana Crha, Igor Diagnostics (Basel) Review The compounds of seminal plasma have great potential as biomarkers of male fertility and can be used as a diagnostic tool for types of azoospermia. Azoospermia occurs in approximately 1% of the male population, and for an effective therapy of this form of male infertility, it is important to distinguish between obstructive and non-obstructive azoospermia. Proteins in seminal plasma can serve as biomarkers for diagnosing azoospermia. Considering the various types of obstructions, a combination of multiple proteins is advisable for diagnostic purposes. In this context, testicular and epididymal proteins are particularly significant, as they are specific to these tissues and typically absent in ejaculate during most obstructions. A combination of multiple biomarkers is more effective than the analysis of a single protein. This group of markers contains TEX101 and ECM1 proteins, combined detections of these two bring a diagnostic output with a high sensitivity and specificity. Similar results were observed for combined detection of TEX101 and SPAG1. The effective using of specific biomarkers from seminal plasma can significantly improve the existing approaches to diagnosis of the causes of male infertility. MDPI 2023-07-25 /pmc/articles/PMC10417070/ /pubmed/37568830 http://dx.doi.org/10.3390/diagnostics13152468 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ješeta, Michal
Pospíšilová, Anna
Mekiňová, Lenka
Franzová, Kateřina
Ventruba, Pavel
Lousová, Eva
Kempisty, Bartosz
Oždian, Tomáš
Žáková, Jana
Crha, Igor
Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins
title Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins
title_full Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins
title_fullStr Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins
title_full_unstemmed Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins
title_short Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins
title_sort non-invasive diagnostics of male spermatogenesis from seminal plasma: seminal proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417070/
https://www.ncbi.nlm.nih.gov/pubmed/37568830
http://dx.doi.org/10.3390/diagnostics13152468
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