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A Novel Paradigm for Non-Invasive Prenatal Genetic Screening: Trophoblast Retrieval and Isolation from the Cervix (TRIC)

As the prevalence of pregnancies with advanced maternal age increases, the risk of fetal chromosomal abnormalities is on the rise. Therefore, prenatal genetic screening and diagnosis have become essential elements in contemporary obstetrical care. Trophoblast retrieval and isolation from the cervix...

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Autores principales: Hong, Kirim, Park, Hee Jin, Jang, Hee Yeon, Shim, Sung Han, Jang, Yoon, Kim, Soo Hyun, Cha, Dong Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417081/
https://www.ncbi.nlm.nih.gov/pubmed/37568895
http://dx.doi.org/10.3390/diagnostics13152532
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author Hong, Kirim
Park, Hee Jin
Jang, Hee Yeon
Shim, Sung Han
Jang, Yoon
Kim, Soo Hyun
Cha, Dong Hyun
author_facet Hong, Kirim
Park, Hee Jin
Jang, Hee Yeon
Shim, Sung Han
Jang, Yoon
Kim, Soo Hyun
Cha, Dong Hyun
author_sort Hong, Kirim
collection PubMed
description As the prevalence of pregnancies with advanced maternal age increases, the risk of fetal chromosomal abnormalities is on the rise. Therefore, prenatal genetic screening and diagnosis have become essential elements in contemporary obstetrical care. Trophoblast retrieval and isolation from the cervix (TRIC) is a non-invasive procedure that can be utilized for prenatal genetic diagnosis. The method involves the isolation of fetal cells (extravillous trophoblasts) by transcervical sampling; along with its non-invasiveness, TRIC exhibits many other advantages such as its usefulness in early pregnancy at 5 weeks of gestation, and no interference by various fetal and maternal factors. Moreover, the trophoblast yields from TRIC can provide valuable information about obstetrical complications related to abnormal placentation even before clinical symptoms arise. The standardization of this clinical tool is still under investigation, and the upcoming advancements in TRIC are expected to meet the increasing need for a safe and accurate option for prenatal diagnosis.
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spelling pubmed-104170812023-08-12 A Novel Paradigm for Non-Invasive Prenatal Genetic Screening: Trophoblast Retrieval and Isolation from the Cervix (TRIC) Hong, Kirim Park, Hee Jin Jang, Hee Yeon Shim, Sung Han Jang, Yoon Kim, Soo Hyun Cha, Dong Hyun Diagnostics (Basel) Review As the prevalence of pregnancies with advanced maternal age increases, the risk of fetal chromosomal abnormalities is on the rise. Therefore, prenatal genetic screening and diagnosis have become essential elements in contemporary obstetrical care. Trophoblast retrieval and isolation from the cervix (TRIC) is a non-invasive procedure that can be utilized for prenatal genetic diagnosis. The method involves the isolation of fetal cells (extravillous trophoblasts) by transcervical sampling; along with its non-invasiveness, TRIC exhibits many other advantages such as its usefulness in early pregnancy at 5 weeks of gestation, and no interference by various fetal and maternal factors. Moreover, the trophoblast yields from TRIC can provide valuable information about obstetrical complications related to abnormal placentation even before clinical symptoms arise. The standardization of this clinical tool is still under investigation, and the upcoming advancements in TRIC are expected to meet the increasing need for a safe and accurate option for prenatal diagnosis. MDPI 2023-07-30 /pmc/articles/PMC10417081/ /pubmed/37568895 http://dx.doi.org/10.3390/diagnostics13152532 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hong, Kirim
Park, Hee Jin
Jang, Hee Yeon
Shim, Sung Han
Jang, Yoon
Kim, Soo Hyun
Cha, Dong Hyun
A Novel Paradigm for Non-Invasive Prenatal Genetic Screening: Trophoblast Retrieval and Isolation from the Cervix (TRIC)
title A Novel Paradigm for Non-Invasive Prenatal Genetic Screening: Trophoblast Retrieval and Isolation from the Cervix (TRIC)
title_full A Novel Paradigm for Non-Invasive Prenatal Genetic Screening: Trophoblast Retrieval and Isolation from the Cervix (TRIC)
title_fullStr A Novel Paradigm for Non-Invasive Prenatal Genetic Screening: Trophoblast Retrieval and Isolation from the Cervix (TRIC)
title_full_unstemmed A Novel Paradigm for Non-Invasive Prenatal Genetic Screening: Trophoblast Retrieval and Isolation from the Cervix (TRIC)
title_short A Novel Paradigm for Non-Invasive Prenatal Genetic Screening: Trophoblast Retrieval and Isolation from the Cervix (TRIC)
title_sort novel paradigm for non-invasive prenatal genetic screening: trophoblast retrieval and isolation from the cervix (tric)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417081/
https://www.ncbi.nlm.nih.gov/pubmed/37568895
http://dx.doi.org/10.3390/diagnostics13152532
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