Phase 2 trial of palbociclib and ganitumab in patients with relapsed Ewing sarcoma

BACKGROUND: Ewing sarcoma (EWS) is an aggressive sarcoma with few treatment options for patients with relapsed disease. Cyclin‐dependent kinase 4 (CDK4) is a genomic vulnerability in EWS that is synergistic with IGF‐1R inhibition in preclinical studies. We present the results of a phase 2 study comb...

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Detalles Bibliográficos
Autores principales: Shulman, David S., Merriam, Priscilla, Choy, Edwin, Guenther, Lillian M., Cavanaugh, Kerri L., Kao, Pei‐Chi, Posner, Andrew, Bhushan, Ketki, Fairchild, Grace, Barker, Emma, Klega, Kelly, Stegmaier, Kimberly, Crompton, Brian D., London, Wendy B., DuBois, Steven G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417097/
https://www.ncbi.nlm.nih.gov/pubmed/37306107
http://dx.doi.org/10.1002/cam4.6208

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