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Ectodomain Shedding by ADAM17 Increases the Release of Soluble CD40 from Human Endothelial Cells under Pro-Inflammatory Conditions

Background: Homozygosity for the C allele of the −1T>C single nucleotide polymorphism (SNP) of the CD40 gene (rs1883832) is associated with susceptibility to coronary heart disease (CHD), enhanced CD40 expression, and shedding. The disintegrin metalloprotease ADAM17 can cleave various cell surfac...

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Detalles Bibliográficos
Autores principales:	Klersy, Anton, Meyer, Sören, Leuschner, Florian, Kessler, Thorsten, Hecker, Markus, Wagner, Andreas H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417149/ https://www.ncbi.nlm.nih.gov/pubmed/37566005 http://dx.doi.org/10.3390/cells12151926

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