Investigation of Different Library Preparation and Tissue of Origin Deconvolution Methods for Urine and Plasma cfDNA Methylome Analysis

Methylation sequencing is a promising approach to infer the tissue of origin of cell-free DNA (cfDNA). In this study, a single- and a double-stranded library preparation approach were evaluated with respect to their technical biases when applied on cfDNA from plasma and urine. Additionally, tissue o...

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Detalles Bibliográficos
Autores principales: Kueng, Nicholas, Sidler, Daniel, Banz, Vanessa, Largiadèr, Carlo R., Ng, Charlotte K. Y., Amstutz, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417284/
https://www.ncbi.nlm.nih.gov/pubmed/37568867
http://dx.doi.org/10.3390/diagnostics13152505

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