Cargando…

Risk factors of postoperative bile leakage after liver resection: A systematic review and meta‐analysis

OBJECTIVE: Postoperative bile leakage (POBL) is one of the most common complications after liver resection. However, current studies on the risk factors for POBL and their impacts on surgical outcomes need to be more consistent. This study aims to conduct a meta‐analysis to analyze the risk factors...

Descripción completa

Detalles Bibliográficos
Autores principales: Xue, Shuai, Wang, Haichuan, Chen, Xiangzheng, Zeng, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417307/
https://www.ncbi.nlm.nih.gov/pubmed/37326370
http://dx.doi.org/10.1002/cam4.6128
_version_ 1785087999457886208
author Xue, Shuai
Wang, Haichuan
Chen, Xiangzheng
Zeng, Yong
author_facet Xue, Shuai
Wang, Haichuan
Chen, Xiangzheng
Zeng, Yong
author_sort Xue, Shuai
collection PubMed
description OBJECTIVE: Postoperative bile leakage (POBL) is one of the most common complications after liver resection. However, current studies on the risk factors for POBL and their impacts on surgical outcomes need to be more consistent. This study aims to conduct a meta‐analysis to analyze the risk factors for POBL after hepatectomy. METHODS: We incorporated all eligible studies from Embase, PubMed, and the Web of Science database (until July 2022) into this study. RevMan and STATA software were used to analyze the extracted data. RESULTS: A total of 39 studies, including 43,824 patients, were included in this meta‐analysis. We found that gender, partial hepatectomy, repeat of hepatectomy, extended hepatectomy, abdominal drain, diabetes, Child≥B, solitary tumor, and chemotherapy are the factors of grade B and C POBL. Some recognized risk factors were considered potential risk factors for grade B and C bile leakage because no subgroup analysis was performed, like HCC, cholangiocarcinoma, major resection, posterior sectionectomy, bi‐segmentectomy, S4 involved, S8 involved, central hepatectomy, and bile duct resection/reconstruction. Meanwhile, cirrhosis, benign diseases, left hepatectomy, and Segment 1 resection were not significant for grade B and C bile leakage. The influence of lateral sectionectomy, anterior sectionectomy, S1 involved, S3 involved, high‐risk procedure, laparoscope, and blood loss>1000 mL on POBL of ISGLS needs further research. Meanwhile, POBL significantly influenced overall survival (OS) after liver resection. CONCLUSIONS: We identified several risk factors for POBL after hepatectomy, which could prompt the clinician to decrease POBL rates and make more beneficial decisions for patients who underwent the hepatectomy.
format Online
Article
Text
id pubmed-10417307
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-104173072023-08-12 Risk factors of postoperative bile leakage after liver resection: A systematic review and meta‐analysis Xue, Shuai Wang, Haichuan Chen, Xiangzheng Zeng, Yong Cancer Med RESEARCH ARTICLES OBJECTIVE: Postoperative bile leakage (POBL) is one of the most common complications after liver resection. However, current studies on the risk factors for POBL and their impacts on surgical outcomes need to be more consistent. This study aims to conduct a meta‐analysis to analyze the risk factors for POBL after hepatectomy. METHODS: We incorporated all eligible studies from Embase, PubMed, and the Web of Science database (until July 2022) into this study. RevMan and STATA software were used to analyze the extracted data. RESULTS: A total of 39 studies, including 43,824 patients, were included in this meta‐analysis. We found that gender, partial hepatectomy, repeat of hepatectomy, extended hepatectomy, abdominal drain, diabetes, Child≥B, solitary tumor, and chemotherapy are the factors of grade B and C POBL. Some recognized risk factors were considered potential risk factors for grade B and C bile leakage because no subgroup analysis was performed, like HCC, cholangiocarcinoma, major resection, posterior sectionectomy, bi‐segmentectomy, S4 involved, S8 involved, central hepatectomy, and bile duct resection/reconstruction. Meanwhile, cirrhosis, benign diseases, left hepatectomy, and Segment 1 resection were not significant for grade B and C bile leakage. The influence of lateral sectionectomy, anterior sectionectomy, S1 involved, S3 involved, high‐risk procedure, laparoscope, and blood loss>1000 mL on POBL of ISGLS needs further research. Meanwhile, POBL significantly influenced overall survival (OS) after liver resection. CONCLUSIONS: We identified several risk factors for POBL after hepatectomy, which could prompt the clinician to decrease POBL rates and make more beneficial decisions for patients who underwent the hepatectomy. John Wiley and Sons Inc. 2023-06-16 /pmc/articles/PMC10417307/ /pubmed/37326370 http://dx.doi.org/10.1002/cam4.6128 Text en © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle RESEARCH ARTICLES
Xue, Shuai
Wang, Haichuan
Chen, Xiangzheng
Zeng, Yong
Risk factors of postoperative bile leakage after liver resection: A systematic review and meta‐analysis
title Risk factors of postoperative bile leakage after liver resection: A systematic review and meta‐analysis
title_full Risk factors of postoperative bile leakage after liver resection: A systematic review and meta‐analysis
title_fullStr Risk factors of postoperative bile leakage after liver resection: A systematic review and meta‐analysis
title_full_unstemmed Risk factors of postoperative bile leakage after liver resection: A systematic review and meta‐analysis
title_short Risk factors of postoperative bile leakage after liver resection: A systematic review and meta‐analysis
title_sort risk factors of postoperative bile leakage after liver resection: a systematic review and meta‐analysis
topic RESEARCH ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417307/
https://www.ncbi.nlm.nih.gov/pubmed/37326370
http://dx.doi.org/10.1002/cam4.6128
work_keys_str_mv AT xueshuai riskfactorsofpostoperativebileleakageafterliverresectionasystematicreviewandmetaanalysis
AT wanghaichuan riskfactorsofpostoperativebileleakageafterliverresectionasystematicreviewandmetaanalysis
AT chenxiangzheng riskfactorsofpostoperativebileleakageafterliverresectionasystematicreviewandmetaanalysis
AT zengyong riskfactorsofpostoperativebileleakageafterliverresectionasystematicreviewandmetaanalysis