Cargando…

Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis

Sarcoidosis is a systemic, granulomatous disease of unknown etiology, most often manifested by mediastinal and hilar lymph node enlargement and parenchymal nodules in the lungs. However, it may involve any other organ. Neuro-sarcoidosis, a condition that affects up to 20% of sarcoidosis patients, ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Zimna, Katarzyna, Szturmowicz, Monika, Sobiecka, Małgorzata, Błasińska, Katarzyna, Bartosiewicz, Małgorzata, Tomkowski, Witold Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417309/
https://www.ncbi.nlm.nih.gov/pubmed/37568942
http://dx.doi.org/10.3390/diagnostics13152579
_version_ 1785088000183500800
author Zimna, Katarzyna
Szturmowicz, Monika
Sobiecka, Małgorzata
Błasińska, Katarzyna
Bartosiewicz, Małgorzata
Tomkowski, Witold Z.
author_facet Zimna, Katarzyna
Szturmowicz, Monika
Sobiecka, Małgorzata
Błasińska, Katarzyna
Bartosiewicz, Małgorzata
Tomkowski, Witold Z.
author_sort Zimna, Katarzyna
collection PubMed
description Sarcoidosis is a systemic, granulomatous disease of unknown etiology, most often manifested by mediastinal and hilar lymph node enlargement and parenchymal nodules in the lungs. However, it may involve any other organ. Neuro-sarcoidosis, a condition that affects up to 20% of sarcoidosis patients, can be found in any part of the central or peripheral nervous system and has important ophthalmic and neuro-ophthalmic manifestations. We present two patients with sudden vision loss due to neurosarcoidosis. In both cases, biopsy of the mediastinal lymph node showed non-caseating granulomas consistent with sarcoidosis. Treatment involved high doses of methylprednisolone intravenously, followed by topical dexamethasone eye drops in the first case and a systemic steroid treatment in the second, resulting in symptom relief. Those two cases demonstrate that sarcoidosis should be considered as a differential diagnosis in cases of optic neuritis.
format Online
Article
Text
id pubmed-10417309
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104173092023-08-12 Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis Zimna, Katarzyna Szturmowicz, Monika Sobiecka, Małgorzata Błasińska, Katarzyna Bartosiewicz, Małgorzata Tomkowski, Witold Z. Diagnostics (Basel) Case Report Sarcoidosis is a systemic, granulomatous disease of unknown etiology, most often manifested by mediastinal and hilar lymph node enlargement and parenchymal nodules in the lungs. However, it may involve any other organ. Neuro-sarcoidosis, a condition that affects up to 20% of sarcoidosis patients, can be found in any part of the central or peripheral nervous system and has important ophthalmic and neuro-ophthalmic manifestations. We present two patients with sudden vision loss due to neurosarcoidosis. In both cases, biopsy of the mediastinal lymph node showed non-caseating granulomas consistent with sarcoidosis. Treatment involved high doses of methylprednisolone intravenously, followed by topical dexamethasone eye drops in the first case and a systemic steroid treatment in the second, resulting in symptom relief. Those two cases demonstrate that sarcoidosis should be considered as a differential diagnosis in cases of optic neuritis. MDPI 2023-08-03 /pmc/articles/PMC10417309/ /pubmed/37568942 http://dx.doi.org/10.3390/diagnostics13152579 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Zimna, Katarzyna
Szturmowicz, Monika
Sobiecka, Małgorzata
Błasińska, Katarzyna
Bartosiewicz, Małgorzata
Tomkowski, Witold Z.
Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis
title Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis
title_full Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis
title_fullStr Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis
title_full_unstemmed Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis
title_short Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis
title_sort sudden vision loss due to optic neuritis—an uncommon presentation of neurosarcoidosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417309/
https://www.ncbi.nlm.nih.gov/pubmed/37568942
http://dx.doi.org/10.3390/diagnostics13152579
work_keys_str_mv AT zimnakatarzyna suddenvisionlossduetoopticneuritisanuncommonpresentationofneurosarcoidosis
AT szturmowiczmonika suddenvisionlossduetoopticneuritisanuncommonpresentationofneurosarcoidosis
AT sobieckamałgorzata suddenvisionlossduetoopticneuritisanuncommonpresentationofneurosarcoidosis
AT błasinskakatarzyna suddenvisionlossduetoopticneuritisanuncommonpresentationofneurosarcoidosis
AT bartosiewiczmałgorzata suddenvisionlossduetoopticneuritisanuncommonpresentationofneurosarcoidosis
AT tomkowskiwitoldz suddenvisionlossduetoopticneuritisanuncommonpresentationofneurosarcoidosis