Doxorubicin Changes the Spatial Organization of the Genome around Active Promoters

In this study, we delve into the impact of genotoxic anticancer drug treatment on the chromatin structure of human cells, with a particular focus on the effects of doxorubicin. Using Hi-C, ChIP-seq, and RNA-seq, we explore the changes in chromatin architecture brought about by doxorubicin and ICRF19...

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Detalles Bibliográficos
Autores principales: Stefanova, Maria E., Ing-Simmons, Elizabeth, Stefanov, Stefan, Flyamer, Ilya, Dorado Garcia, Heathcliff, Schöpflin, Robert, Henssen, Anton G., Vaquerizas, Juan M., Mundlos, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417312/
https://www.ncbi.nlm.nih.gov/pubmed/37566080
http://dx.doi.org/10.3390/cells12152001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417312/
https://www.ncbi.nlm.nih.gov/pubmed/37566080
http://dx.doi.org/10.3390/cells12152001

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