Crosstalk between Cancer Cells and Cancer-Associated Fibroblasts Mediated by TGF-β1–IGFBP7 Signaling Promotes the Progression of Infiltrative Gastric Cancer

SIMPLE SUMMARY: This study clarified that in the tumor microenvironment, tumor cell-derived TGF-β1 induces the appearance of an IGFBP7(+) CAFs subgroup, and its higher IGFBP7 extracellular secretion level accelerated the progression of tumors. Our work suggests that IGFBP7 is a novel predictive mark...

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Detalles Bibliográficos
Autores principales: Hong, Zhijun, Xie, Wen, Zhuo, Huiqin, Wei, Xujin, Wang, Kang, Cheng, Jia, Lin, Lingyun, Hou, Jingjing, Chen, Xin, Cai, Jianchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417438/
https://www.ncbi.nlm.nih.gov/pubmed/37568781
http://dx.doi.org/10.3390/cancers15153965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417438/
https://www.ncbi.nlm.nih.gov/pubmed/37568781
http://dx.doi.org/10.3390/cancers15153965

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