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Crosstalk between Cancer Cells and Cancer-Associated Fibroblasts Mediated by TGF-β1–IGFBP7 Signaling Promotes the Progression of Infiltrative Gastric Cancer

SIMPLE SUMMARY: This study clarified that in the tumor microenvironment, tumor cell-derived TGF-β1 induces the appearance of an IGFBP7(+) CAFs subgroup, and its higher IGFBP7 extracellular secretion level accelerated the progression of tumors. Our work suggests that IGFBP7 is a novel predictive mark...

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Detalles Bibliográficos
Autores principales:	Hong, Zhijun, Xie, Wen, Zhuo, Huiqin, Wei, Xujin, Wang, Kang, Cheng, Jia, Lin, Lingyun, Hou, Jingjing, Chen, Xin, Cai, Jianchun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417438/ https://www.ncbi.nlm.nih.gov/pubmed/37568781 http://dx.doi.org/10.3390/cancers15153965

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