Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation

ALDH1B1 expressed in the intestinal epithelium metabolises acetaldehyde to acetate, protecting against acetaldehyde-induced DNA damage. MSH2 is a key component of the DNA mismatch repair (MMR) pathway involved in Lynch syndrome (LS)-associated colorectal cancers. Here, we show that defective MMR (dM...

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Detalles Bibliográficos
Autores principales: Cerretelli, Guia, Zhou, Ying, Müller, Mike F., Adams, David J., Arends, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417510/
https://www.ncbi.nlm.nih.gov/pubmed/37395714
http://dx.doi.org/10.1242/dmm.050240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417510/
https://www.ncbi.nlm.nih.gov/pubmed/37395714
http://dx.doi.org/10.1242/dmm.050240

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