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Pericyte Loss in Diseases

Pericytes are specialized cells located in close proximity to endothelial cells within the microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls, and maintaining the integrity of the blood–brain barrier. The loss of pericytes has been associated with the devel...

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Detalles Bibliográficos
Autores principales: Li, Pengfei, Fan, Hongkuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417558/
https://www.ncbi.nlm.nih.gov/pubmed/37566011
http://dx.doi.org/10.3390/cells12151931
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author Li, Pengfei
Fan, Hongkuan
author_facet Li, Pengfei
Fan, Hongkuan
author_sort Li, Pengfei
collection PubMed
description Pericytes are specialized cells located in close proximity to endothelial cells within the microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls, and maintaining the integrity of the blood–brain barrier. The loss of pericytes has been associated with the development and progression of various diseases, such as diabetes, Alzheimer’s disease, sepsis, stroke, and traumatic brain injury. This review examines the detection of pericyte loss in different diseases, explores the methods employed to assess pericyte coverage, and elucidates the potential mechanisms contributing to pericyte loss in these pathological conditions. Additionally, current therapeutic strategies targeting pericytes are discussed, along with potential future interventions aimed at preserving pericyte function and promoting disease mitigation.
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spelling pubmed-104175582023-08-12 Pericyte Loss in Diseases Li, Pengfei Fan, Hongkuan Cells Review Pericytes are specialized cells located in close proximity to endothelial cells within the microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls, and maintaining the integrity of the blood–brain barrier. The loss of pericytes has been associated with the development and progression of various diseases, such as diabetes, Alzheimer’s disease, sepsis, stroke, and traumatic brain injury. This review examines the detection of pericyte loss in different diseases, explores the methods employed to assess pericyte coverage, and elucidates the potential mechanisms contributing to pericyte loss in these pathological conditions. Additionally, current therapeutic strategies targeting pericytes are discussed, along with potential future interventions aimed at preserving pericyte function and promoting disease mitigation. MDPI 2023-07-26 /pmc/articles/PMC10417558/ /pubmed/37566011 http://dx.doi.org/10.3390/cells12151931 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Pengfei
Fan, Hongkuan
Pericyte Loss in Diseases
title Pericyte Loss in Diseases
title_full Pericyte Loss in Diseases
title_fullStr Pericyte Loss in Diseases
title_full_unstemmed Pericyte Loss in Diseases
title_short Pericyte Loss in Diseases
title_sort pericyte loss in diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417558/
https://www.ncbi.nlm.nih.gov/pubmed/37566011
http://dx.doi.org/10.3390/cells12151931
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