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Pericyte Loss in Diseases
Pericytes are specialized cells located in close proximity to endothelial cells within the microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls, and maintaining the integrity of the blood–brain barrier. The loss of pericytes has been associated with the devel...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417558/ https://www.ncbi.nlm.nih.gov/pubmed/37566011 http://dx.doi.org/10.3390/cells12151931 |
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author | Li, Pengfei Fan, Hongkuan |
author_facet | Li, Pengfei Fan, Hongkuan |
author_sort | Li, Pengfei |
collection | PubMed |
description | Pericytes are specialized cells located in close proximity to endothelial cells within the microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls, and maintaining the integrity of the blood–brain barrier. The loss of pericytes has been associated with the development and progression of various diseases, such as diabetes, Alzheimer’s disease, sepsis, stroke, and traumatic brain injury. This review examines the detection of pericyte loss in different diseases, explores the methods employed to assess pericyte coverage, and elucidates the potential mechanisms contributing to pericyte loss in these pathological conditions. Additionally, current therapeutic strategies targeting pericytes are discussed, along with potential future interventions aimed at preserving pericyte function and promoting disease mitigation. |
format | Online Article Text |
id | pubmed-10417558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104175582023-08-12 Pericyte Loss in Diseases Li, Pengfei Fan, Hongkuan Cells Review Pericytes are specialized cells located in close proximity to endothelial cells within the microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls, and maintaining the integrity of the blood–brain barrier. The loss of pericytes has been associated with the development and progression of various diseases, such as diabetes, Alzheimer’s disease, sepsis, stroke, and traumatic brain injury. This review examines the detection of pericyte loss in different diseases, explores the methods employed to assess pericyte coverage, and elucidates the potential mechanisms contributing to pericyte loss in these pathological conditions. Additionally, current therapeutic strategies targeting pericytes are discussed, along with potential future interventions aimed at preserving pericyte function and promoting disease mitigation. MDPI 2023-07-26 /pmc/articles/PMC10417558/ /pubmed/37566011 http://dx.doi.org/10.3390/cells12151931 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Pengfei Fan, Hongkuan Pericyte Loss in Diseases |
title | Pericyte Loss in Diseases |
title_full | Pericyte Loss in Diseases |
title_fullStr | Pericyte Loss in Diseases |
title_full_unstemmed | Pericyte Loss in Diseases |
title_short | Pericyte Loss in Diseases |
title_sort | pericyte loss in diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417558/ https://www.ncbi.nlm.nih.gov/pubmed/37566011 http://dx.doi.org/10.3390/cells12151931 |
work_keys_str_mv | AT lipengfei pericytelossindiseases AT fanhongkuan pericytelossindiseases |