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The Role of Cytokines in Neutrophil Development, Tissue Homing, Function and Plasticity in Health and Disease
Neutrophils are crucial innate immune cells and comprise 50–70% of the white blood cell population under homeostatic conditions. Upon infection and in cancer, blood neutrophil numbers significantly increase because of the secretion of various chemo- and cytokines by, e.g., leukocytes, pericytes, fib...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417597/ https://www.ncbi.nlm.nih.gov/pubmed/37566060 http://dx.doi.org/10.3390/cells12151981 |
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author | Tsioumpekou, Maria Krijgsman, Daniëlle Leusen, Jeanette H. W. Olofsen, Patricia A. |
author_facet | Tsioumpekou, Maria Krijgsman, Daniëlle Leusen, Jeanette H. W. Olofsen, Patricia A. |
author_sort | Tsioumpekou, Maria |
collection | PubMed |
description | Neutrophils are crucial innate immune cells and comprise 50–70% of the white blood cell population under homeostatic conditions. Upon infection and in cancer, blood neutrophil numbers significantly increase because of the secretion of various chemo- and cytokines by, e.g., leukocytes, pericytes, fibroblasts and endothelial cells present in the inflamed tissue or in the tumor microenvironment (TME). The function of neutrophils in cancer has recently gained considerable attention, as they can exert both pro- and anti-tumorigenic functions, dependent on the cytokine milieu present in the TME. Here, we review the effect of cytokines on neutrophil development, tissue homing, function and plasticity in cancer and autoimmune diseases as well as under physiological conditions in the bone marrow, bloodstream and various organs like the spleen, kidney, liver, lung and lymph nodes. In addition, we address several promising therapeutic options, such as cytokine therapy, immunocytokines and immunotherapy, which aim to exploit the anti-tumorigenic potential of neutrophils in cancer treatment or block excessive neutrophil-mediated inflammation in autoimmune diseases. |
format | Online Article Text |
id | pubmed-10417597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104175972023-08-12 The Role of Cytokines in Neutrophil Development, Tissue Homing, Function and Plasticity in Health and Disease Tsioumpekou, Maria Krijgsman, Daniëlle Leusen, Jeanette H. W. Olofsen, Patricia A. Cells Review Neutrophils are crucial innate immune cells and comprise 50–70% of the white blood cell population under homeostatic conditions. Upon infection and in cancer, blood neutrophil numbers significantly increase because of the secretion of various chemo- and cytokines by, e.g., leukocytes, pericytes, fibroblasts and endothelial cells present in the inflamed tissue or in the tumor microenvironment (TME). The function of neutrophils in cancer has recently gained considerable attention, as they can exert both pro- and anti-tumorigenic functions, dependent on the cytokine milieu present in the TME. Here, we review the effect of cytokines on neutrophil development, tissue homing, function and plasticity in cancer and autoimmune diseases as well as under physiological conditions in the bone marrow, bloodstream and various organs like the spleen, kidney, liver, lung and lymph nodes. In addition, we address several promising therapeutic options, such as cytokine therapy, immunocytokines and immunotherapy, which aim to exploit the anti-tumorigenic potential of neutrophils in cancer treatment or block excessive neutrophil-mediated inflammation in autoimmune diseases. MDPI 2023-07-31 /pmc/articles/PMC10417597/ /pubmed/37566060 http://dx.doi.org/10.3390/cells12151981 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tsioumpekou, Maria Krijgsman, Daniëlle Leusen, Jeanette H. W. Olofsen, Patricia A. The Role of Cytokines in Neutrophil Development, Tissue Homing, Function and Plasticity in Health and Disease |
title | The Role of Cytokines in Neutrophil Development, Tissue Homing, Function and Plasticity in Health and Disease |
title_full | The Role of Cytokines in Neutrophil Development, Tissue Homing, Function and Plasticity in Health and Disease |
title_fullStr | The Role of Cytokines in Neutrophil Development, Tissue Homing, Function and Plasticity in Health and Disease |
title_full_unstemmed | The Role of Cytokines in Neutrophil Development, Tissue Homing, Function and Plasticity in Health and Disease |
title_short | The Role of Cytokines in Neutrophil Development, Tissue Homing, Function and Plasticity in Health and Disease |
title_sort | role of cytokines in neutrophil development, tissue homing, function and plasticity in health and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417597/ https://www.ncbi.nlm.nih.gov/pubmed/37566060 http://dx.doi.org/10.3390/cells12151981 |
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