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Routine Brain MRI Findings on the Long-Term Effects of COVID-19: A Scoping Review

Rationale and Objectives: Post-COVID condition (PCC) is associated with long-term neuropsychiatric symptoms. Magnetic resonance imaging (MRI) in PCC examines the brain metabolism, connectivity, and morphometry. Such techniques are not easily available in routine practice. We conducted a scoping revi...

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Autores principales: Vasilev, Yuriy, Blokhin, Ivan, Khoruzhaya, Anna, Kodenko, Maria, Kolyshenkov, Vasiliy, Nanova, Olga, Shumskaya, Yuliya, Omelyanskaya, Olga, Vladzymyrskyy, Anton, Reshetnikov, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417725/
https://www.ncbi.nlm.nih.gov/pubmed/37568896
http://dx.doi.org/10.3390/diagnostics13152533
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author Vasilev, Yuriy
Blokhin, Ivan
Khoruzhaya, Anna
Kodenko, Maria
Kolyshenkov, Vasiliy
Nanova, Olga
Shumskaya, Yuliya
Omelyanskaya, Olga
Vladzymyrskyy, Anton
Reshetnikov, Roman
author_facet Vasilev, Yuriy
Blokhin, Ivan
Khoruzhaya, Anna
Kodenko, Maria
Kolyshenkov, Vasiliy
Nanova, Olga
Shumskaya, Yuliya
Omelyanskaya, Olga
Vladzymyrskyy, Anton
Reshetnikov, Roman
author_sort Vasilev, Yuriy
collection PubMed
description Rationale and Objectives: Post-COVID condition (PCC) is associated with long-term neuropsychiatric symptoms. Magnetic resonance imaging (MRI) in PCC examines the brain metabolism, connectivity, and morphometry. Such techniques are not easily available in routine practice. We conducted a scoping review to determine what is known about the routine MRI findings in PCC patients. Materials and Methods: The PubMed database was searched up to 11 April 2023. We included cohort, cross-sectional, and before–after studies in English. Articles with only advanced MRI sequences (DTI, fMRI, VBM, PWI, ASL), preprints, and case reports were excluded. The National Heart, Lung, and Blood Institute and PRISMA Extension tools were used for quality assurance. Results: A total of 7 citations out of 167 were included. The total sample size was 451 patients (average age 51 ± 8 years; 67% female). Five studies followed a single recovering cohort, while two studies compared findings between two severity groups. The MRI findings were perivascular spaces (47%), microbleeds (27%) and white matter lesions (10%). All the studies agreed that PCC manifestations are not associated with specific MRI findings. Conclusion: The results of the included studies are heterogeneous due to the low agreement on the types of MRI abnormalities in PCC. Our findings indicate that the routine brain MRI protocol has little value for long COVID diagnostics.
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spelling pubmed-104177252023-08-12 Routine Brain MRI Findings on the Long-Term Effects of COVID-19: A Scoping Review Vasilev, Yuriy Blokhin, Ivan Khoruzhaya, Anna Kodenko, Maria Kolyshenkov, Vasiliy Nanova, Olga Shumskaya, Yuliya Omelyanskaya, Olga Vladzymyrskyy, Anton Reshetnikov, Roman Diagnostics (Basel) Systematic Review Rationale and Objectives: Post-COVID condition (PCC) is associated with long-term neuropsychiatric symptoms. Magnetic resonance imaging (MRI) in PCC examines the brain metabolism, connectivity, and morphometry. Such techniques are not easily available in routine practice. We conducted a scoping review to determine what is known about the routine MRI findings in PCC patients. Materials and Methods: The PubMed database was searched up to 11 April 2023. We included cohort, cross-sectional, and before–after studies in English. Articles with only advanced MRI sequences (DTI, fMRI, VBM, PWI, ASL), preprints, and case reports were excluded. The National Heart, Lung, and Blood Institute and PRISMA Extension tools were used for quality assurance. Results: A total of 7 citations out of 167 were included. The total sample size was 451 patients (average age 51 ± 8 years; 67% female). Five studies followed a single recovering cohort, while two studies compared findings between two severity groups. The MRI findings were perivascular spaces (47%), microbleeds (27%) and white matter lesions (10%). All the studies agreed that PCC manifestations are not associated with specific MRI findings. Conclusion: The results of the included studies are heterogeneous due to the low agreement on the types of MRI abnormalities in PCC. Our findings indicate that the routine brain MRI protocol has little value for long COVID diagnostics. MDPI 2023-07-30 /pmc/articles/PMC10417725/ /pubmed/37568896 http://dx.doi.org/10.3390/diagnostics13152533 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Vasilev, Yuriy
Blokhin, Ivan
Khoruzhaya, Anna
Kodenko, Maria
Kolyshenkov, Vasiliy
Nanova, Olga
Shumskaya, Yuliya
Omelyanskaya, Olga
Vladzymyrskyy, Anton
Reshetnikov, Roman
Routine Brain MRI Findings on the Long-Term Effects of COVID-19: A Scoping Review
title Routine Brain MRI Findings on the Long-Term Effects of COVID-19: A Scoping Review
title_full Routine Brain MRI Findings on the Long-Term Effects of COVID-19: A Scoping Review
title_fullStr Routine Brain MRI Findings on the Long-Term Effects of COVID-19: A Scoping Review
title_full_unstemmed Routine Brain MRI Findings on the Long-Term Effects of COVID-19: A Scoping Review
title_short Routine Brain MRI Findings on the Long-Term Effects of COVID-19: A Scoping Review
title_sort routine brain mri findings on the long-term effects of covid-19: a scoping review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417725/
https://www.ncbi.nlm.nih.gov/pubmed/37568896
http://dx.doi.org/10.3390/diagnostics13152533
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