Cargando…

Changes in the Heart Rate of Sniffer Dogs Trained for Detection of Lung Cancer

Background: Lung carcinoma is one of the most common malignancies worldwide. At present, unfortunately, there are no markers that would allow early identification of this tumor in the preclinical or early clinical stage. The use of sniffer dogs has been reported to show some promise in early diagnos...

Descripción completa

Detalles Bibliográficos
Autores principales: Riedlova, Petra, Tavandzis, Spiros, Kana, Josef, Ostrizkova, Silvie, Kramna, Dagmar, Krajcir, Libor, Kanova, Tereza, Lastikova, Simona, Tomaskova, Hana, Roubec, Jaromir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417766/
https://www.ncbi.nlm.nih.gov/pubmed/37568930
http://dx.doi.org/10.3390/diagnostics13152567
_version_ 1785088117186756608
author Riedlova, Petra
Tavandzis, Spiros
Kana, Josef
Ostrizkova, Silvie
Kramna, Dagmar
Krajcir, Libor
Kanova, Tereza
Lastikova, Simona
Tomaskova, Hana
Roubec, Jaromir
author_facet Riedlova, Petra
Tavandzis, Spiros
Kana, Josef
Ostrizkova, Silvie
Kramna, Dagmar
Krajcir, Libor
Kanova, Tereza
Lastikova, Simona
Tomaskova, Hana
Roubec, Jaromir
author_sort Riedlova, Petra
collection PubMed
description Background: Lung carcinoma is one of the most common malignancies worldwide. At present, unfortunately, there are no markers that would allow early identification of this tumor in the preclinical or early clinical stage. The use of sniffer dogs has been reported to show some promise in early diagnosis of this type of cancer Aim: This study aimed to evaluate the possibility of utilizing changes in the heart rate of sniffer dogs (which increases when finding a positive sample) in tumor detection. Methods: This double-blinded pilot study included two sniffer dogs. A chest strap was fastened on the dog’s chests for heart rate monitoring while they were examining samples and heart rate was recorded. Test parameters (sensitivity, specificity, positive and negative predictive values) were then calculated, evaluating performances based on (i) the dog’s indications according to their training and (ii) the changes in their heart rates. Results: Calculation according to the dog’s indications revealed an overall sensitivity of 95.2% accompanied by a specificity of 81.8%, a PPV of 93.7%, and an NPV of 85.7%, respectively. These results were not significantly different from those evaluated by heart rate; heart rate monitoring was, however, burdened with a relatively high proportion of invalid experiments in which heart rate measurement failed. When the method of calculation was changed from rounds to individual samples, the test parameters further increased. Conclusions: This pilot study confirmed the hypothesis that heart rate increases in trained sniffer dogs when encountering samples from tumor-positive patients but remains unchanged when only negative samples are present. The reliability of results based on heart rate increase is similar to that obtained by a dog’s indications and, if the limitation represented by technical issues is overcome, it could serve as a valuable verification method.
format Online
Article
Text
id pubmed-10417766
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104177662023-08-12 Changes in the Heart Rate of Sniffer Dogs Trained for Detection of Lung Cancer Riedlova, Petra Tavandzis, Spiros Kana, Josef Ostrizkova, Silvie Kramna, Dagmar Krajcir, Libor Kanova, Tereza Lastikova, Simona Tomaskova, Hana Roubec, Jaromir Diagnostics (Basel) Article Background: Lung carcinoma is one of the most common malignancies worldwide. At present, unfortunately, there are no markers that would allow early identification of this tumor in the preclinical or early clinical stage. The use of sniffer dogs has been reported to show some promise in early diagnosis of this type of cancer Aim: This study aimed to evaluate the possibility of utilizing changes in the heart rate of sniffer dogs (which increases when finding a positive sample) in tumor detection. Methods: This double-blinded pilot study included two sniffer dogs. A chest strap was fastened on the dog’s chests for heart rate monitoring while they were examining samples and heart rate was recorded. Test parameters (sensitivity, specificity, positive and negative predictive values) were then calculated, evaluating performances based on (i) the dog’s indications according to their training and (ii) the changes in their heart rates. Results: Calculation according to the dog’s indications revealed an overall sensitivity of 95.2% accompanied by a specificity of 81.8%, a PPV of 93.7%, and an NPV of 85.7%, respectively. These results were not significantly different from those evaluated by heart rate; heart rate monitoring was, however, burdened with a relatively high proportion of invalid experiments in which heart rate measurement failed. When the method of calculation was changed from rounds to individual samples, the test parameters further increased. Conclusions: This pilot study confirmed the hypothesis that heart rate increases in trained sniffer dogs when encountering samples from tumor-positive patients but remains unchanged when only negative samples are present. The reliability of results based on heart rate increase is similar to that obtained by a dog’s indications and, if the limitation represented by technical issues is overcome, it could serve as a valuable verification method. MDPI 2023-08-01 /pmc/articles/PMC10417766/ /pubmed/37568930 http://dx.doi.org/10.3390/diagnostics13152567 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Riedlova, Petra
Tavandzis, Spiros
Kana, Josef
Ostrizkova, Silvie
Kramna, Dagmar
Krajcir, Libor
Kanova, Tereza
Lastikova, Simona
Tomaskova, Hana
Roubec, Jaromir
Changes in the Heart Rate of Sniffer Dogs Trained for Detection of Lung Cancer
title Changes in the Heart Rate of Sniffer Dogs Trained for Detection of Lung Cancer
title_full Changes in the Heart Rate of Sniffer Dogs Trained for Detection of Lung Cancer
title_fullStr Changes in the Heart Rate of Sniffer Dogs Trained for Detection of Lung Cancer
title_full_unstemmed Changes in the Heart Rate of Sniffer Dogs Trained for Detection of Lung Cancer
title_short Changes in the Heart Rate of Sniffer Dogs Trained for Detection of Lung Cancer
title_sort changes in the heart rate of sniffer dogs trained for detection of lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417766/
https://www.ncbi.nlm.nih.gov/pubmed/37568930
http://dx.doi.org/10.3390/diagnostics13152567
work_keys_str_mv AT riedlovapetra changesintheheartrateofsnifferdogstrainedfordetectionoflungcancer
AT tavandzisspiros changesintheheartrateofsnifferdogstrainedfordetectionoflungcancer
AT kanajosef changesintheheartrateofsnifferdogstrainedfordetectionoflungcancer
AT ostrizkovasilvie changesintheheartrateofsnifferdogstrainedfordetectionoflungcancer
AT kramnadagmar changesintheheartrateofsnifferdogstrainedfordetectionoflungcancer
AT krajcirlibor changesintheheartrateofsnifferdogstrainedfordetectionoflungcancer
AT kanovatereza changesintheheartrateofsnifferdogstrainedfordetectionoflungcancer
AT lastikovasimona changesintheheartrateofsnifferdogstrainedfordetectionoflungcancer
AT tomaskovahana changesintheheartrateofsnifferdogstrainedfordetectionoflungcancer
AT roubecjaromir changesintheheartrateofsnifferdogstrainedfordetectionoflungcancer