Sex differences for antipsychotic dosing and how to guide therapy

ABSTRACT: Over the past decades the role of sex in the antipsychotic treatment type and dose selection has been virtually overseen. In fact, medication approval trials barely stratify for sex differences. Emerging hints from different types of data highlight the need for antipsychotic treatment pers...

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Autor principal: Schoretsanitis, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417824/
http://dx.doi.org/10.1192/j.eurpsy.2023.119
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author Schoretsanitis, G.
author_facet Schoretsanitis, G.
author_sort Schoretsanitis, G.
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description ABSTRACT: Over the past decades the role of sex in the antipsychotic treatment type and dose selection has been virtually overseen. In fact, medication approval trials barely stratify for sex differences. Emerging hints from different types of data highlight the need for antipsychotic treatment personalization within the context of sex differences. Varying bioavaibility patterns of the prescribed antipsychotics between female and male patients may be easy to capture measuring plasma or serum levels of the antipsychotics ultimately guiding dose selection in clinical routine. Here we will discuss pitfalls and current evidence regarding sex affecting dose selection to enhance safety and effectiveness outcomes of antipsychotic treatment. DISCLOSURE OF INTEREST: G. Schoretsanitis Consultant of: HLS Therapeutics and ThermoFisher
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spelling pubmed-104178242023-08-12 Sex differences for antipsychotic dosing and how to guide therapy Schoretsanitis, G. Eur Psychiatry Abstract ABSTRACT: Over the past decades the role of sex in the antipsychotic treatment type and dose selection has been virtually overseen. In fact, medication approval trials barely stratify for sex differences. Emerging hints from different types of data highlight the need for antipsychotic treatment personalization within the context of sex differences. Varying bioavaibility patterns of the prescribed antipsychotics between female and male patients may be easy to capture measuring plasma or serum levels of the antipsychotics ultimately guiding dose selection in clinical routine. Here we will discuss pitfalls and current evidence regarding sex affecting dose selection to enhance safety and effectiveness outcomes of antipsychotic treatment. DISCLOSURE OF INTEREST: G. Schoretsanitis Consultant of: HLS Therapeutics and ThermoFisher Cambridge University Press 2023-07-19 /pmc/articles/PMC10417824/ http://dx.doi.org/10.1192/j.eurpsy.2023.119 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Schoretsanitis, G.
Sex differences for antipsychotic dosing and how to guide therapy
title Sex differences for antipsychotic dosing and how to guide therapy
title_full Sex differences for antipsychotic dosing and how to guide therapy
title_fullStr Sex differences for antipsychotic dosing and how to guide therapy
title_full_unstemmed Sex differences for antipsychotic dosing and how to guide therapy
title_short Sex differences for antipsychotic dosing and how to guide therapy
title_sort sex differences for antipsychotic dosing and how to guide therapy
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417824/
http://dx.doi.org/10.1192/j.eurpsy.2023.119
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