Identification of 5-HT(2A) Receptor Signaling Pathways Responsible for Psychedelic Potential

Serotonergic psychedelics possess considerable therapeutic potential. Although 5-HT(2A) receptor activation mediates psychedelic effects, prototypical psychedelics activate both 5-HT(2A)-Gq/11 and β-arrestin2 signaling, making their respective roles unclear. To elucidate this, we developed a series...

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Detalles Bibliográficos
Autores principales: Wallach, Jason, Cao, Andrew B., Calkins, Maggie M., Heim, Andrew J., Lanham, Janelle K., Bonniwell, Emma M., Hennessey, Joseph J., Bock, Hailey A., Anderson, Emilie I., Sherwood, Alexander M., Morris, Hamilton, de Klein, Robbin, Klein, Adam K., Cuccurazzu, Bruna, Gamrat, James, Fannana, Tilka, Zauhar, Randy, Halberstadt, Adam L., McCorvy, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418054/
https://www.ncbi.nlm.nih.gov/pubmed/37577474
http://dx.doi.org/10.1101/2023.07.29.551106

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