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Jointly modeling deep mutational scans identifies shifted mutational effects among SARS-CoV-2 spike homologs

Deep mutational scanning (DMS) is a high-throughput experimental technique that measures the effects of thousands of mutations to a protein. These experiments can be performed on multiple homologs of a protein or on the same protein selected under multiple conditions. It is often of biological inter...

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Detalles Bibliográficos
Autores principales:	Haddox, Hugh K., Galloway, Jared G., Dadonaite, Bernadeta, Bloom, Jesse D., Matsen IV, Frederick A., DeWitt, William S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418112/ https://www.ncbi.nlm.nih.gov/pubmed/37577604 http://dx.doi.org/10.1101/2023.07.31.551037

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