A fibroblast-dependent TGFβ1/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis

Reciprocal interactions between alveolar fibroblasts and epithelial cells are crucial for lung homeostasis, injury repair, and fibrogenesis, but underlying mechanisms remain unclear. To investigate this, we administered the fibroblast-selective TGFβ1 signaling inhibitor, epigallocatechin gallate (EG...

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Detalles Bibliográficos
Autores principales: Cohen, Max L., Brumwell, Alexis N., Che Ho, Tsung, Montas, Genevieve, Golden, Jeffrey A., Jones, Kirk D., Wolters, Paul J., Wei, Ying, Chapman, Harold A., Le Saux, Claude J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418166/
https://www.ncbi.nlm.nih.gov/pubmed/37577522
http://dx.doi.org/10.1101/2023.08.02.551383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418166/
https://www.ncbi.nlm.nih.gov/pubmed/37577522
http://dx.doi.org/10.1101/2023.08.02.551383

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