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Combined kinome inhibition states are predictive of cancer cell line sensitivity to kinase inhibitor combination therapies
Protein kinases are a primary focus in targeted therapy development for cancer, owing to their role as regulators in nearly all areas of cell life. Kinase inhibitors are one of the fastest growing drug classes in oncology, but resistance acquisition to kinase-targeting monotherapies is inevitable du...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418192/ https://www.ncbi.nlm.nih.gov/pubmed/37577663 http://dx.doi.org/10.1101/2023.08.01.551346 |