Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility

Spontaneous neuronal network activity is essential in development of central and peripheral circuits, yet whether this is a feature of enteric nervous system development has yet to be established. Using ex vivo gastrointestinal (GI) motility assays with unbiased computational analyses, we identify a...

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Detalles Bibliográficos
Autores principales: Dershowitz, Lori B., Garcia, Hassler Bueno, Perley, Andrew S., Coleman, Todd P., Kaltschmidt, Julia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418201/
https://www.ncbi.nlm.nih.gov/pubmed/37577464
http://dx.doi.org/10.1101/2023.08.03.551847
Descripción
Sumario:Spontaneous neuronal network activity is essential in development of central and peripheral circuits, yet whether this is a feature of enteric nervous system development has yet to be established. Using ex vivo gastrointestinal (GI) motility assays with unbiased computational analyses, we identify a previously unknown pattern of spontaneous neurogenic GI motility. We further show that this motility is driven by cholinergic signaling, which may inform GI pharmacology for preterm patients.

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