Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility

Spontaneous neuronal network activity is essential in development of central and peripheral circuits, yet whether this is a feature of enteric nervous system development has yet to be established. Using ex vivo gastrointestinal (GI) motility assays with unbiased computational analyses, we identify a...

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Autores principales: Dershowitz, Lori B., Garcia, Hassler Bueno, Perley, Andrew S., Coleman, Todd P., Kaltschmidt, Julia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418201/
https://www.ncbi.nlm.nih.gov/pubmed/37577464
http://dx.doi.org/10.1101/2023.08.03.551847
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author Dershowitz, Lori B.
Garcia, Hassler Bueno
Perley, Andrew S.
Coleman, Todd P.
Kaltschmidt, Julia A.
author_facet Dershowitz, Lori B.
Garcia, Hassler Bueno
Perley, Andrew S.
Coleman, Todd P.
Kaltschmidt, Julia A.
author_sort Dershowitz, Lori B.
collection PubMed
description Spontaneous neuronal network activity is essential in development of central and peripheral circuits, yet whether this is a feature of enteric nervous system development has yet to be established. Using ex vivo gastrointestinal (GI) motility assays with unbiased computational analyses, we identify a previously unknown pattern of spontaneous neurogenic GI motility. We further show that this motility is driven by cholinergic signaling, which may inform GI pharmacology for preterm patients.
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spelling pubmed-104182012023-08-12 Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility Dershowitz, Lori B. Garcia, Hassler Bueno Perley, Andrew S. Coleman, Todd P. Kaltschmidt, Julia A. bioRxiv Article Spontaneous neuronal network activity is essential in development of central and peripheral circuits, yet whether this is a feature of enteric nervous system development has yet to be established. Using ex vivo gastrointestinal (GI) motility assays with unbiased computational analyses, we identify a previously unknown pattern of spontaneous neurogenic GI motility. We further show that this motility is driven by cholinergic signaling, which may inform GI pharmacology for preterm patients. Cold Spring Harbor Laboratory 2023-08-06 /pmc/articles/PMC10418201/ /pubmed/37577464 http://dx.doi.org/10.1101/2023.08.03.551847 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Dershowitz, Lori B.
Garcia, Hassler Bueno
Perley, Andrew S.
Coleman, Todd P.
Kaltschmidt, Julia A.
Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility
title Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility
title_full Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility
title_fullStr Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility
title_full_unstemmed Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility
title_short Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility
title_sort spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418201/
https://www.ncbi.nlm.nih.gov/pubmed/37577464
http://dx.doi.org/10.1101/2023.08.03.551847
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