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XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells

Emerging data suggest that induction of viral mimicry responses through activation of double-stranded RNA (dsRNA) sensors in cancer cells is a promising therapeutic strategy. One approach to induce viral mimicry is to target molecular regulators of dsRNA sensing pathways. Here, we show that the exor...

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Detalles Bibliográficos
Autores principales:	Zou, Tao, Zhou, Meng, Gupta, Akansha, Zhuang, Patrick, Fishbein, Alyssa R., Wei, Hope Y., Zhang, Zhouwei, Cherniack, Andrew D., Meyerson, Matthew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418227/ https://www.ncbi.nlm.nih.gov/pubmed/37577567 http://dx.doi.org/10.1101/2023.08.01.551488

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