Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

MET is a receptor tyrosine kinase (RTK) responsible for initiating signaling pathways involved in development and wound repair. MET activation relies on ligand binding to the extracellular receptor, which prompts dimerization, intracellular phosphorylation, and recruitment of associated signaling pr...

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Detalles Bibliográficos
Autores principales: Estevam, Gabriella O., Linossi, Edmond M., Macdonald, Christian B., Espinoza, Carla A., Michaud, Jennifer M., Coyote-Maestas, Willow, Collisson, Eric A., Jura, Natalia, Fraser, James S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418267/
https://www.ncbi.nlm.nih.gov/pubmed/37577651
http://dx.doi.org/10.1101/2023.08.03.551866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418267/
https://www.ncbi.nlm.nih.gov/pubmed/37577651
http://dx.doi.org/10.1101/2023.08.03.551866

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