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A comprehensive workflow and its validation for simulating diffuse speckle statistics for optical blood flow measurements

Diffuse optical methods including speckle contrast optical spectroscopy and tomography (SCOS and SCOT), use speckle contrast ([Formula: see text]) to measure deep blood flow. In order to design practical systems, parameters such as signal-to-noise ratio (SNR) and the effects of limited sampling of s...

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Detalles Bibliográficos
Autores principales: Frisk, Lisa Kobayashi, Verma, Manish, Bešlija, Faruk, Lin, Chen-Hao P., Patil, Nishighanda, Chetia, Sumana, Trobaugh, Jason, Culver, Joseph P., Durduran, Turgut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418286/
https://www.ncbi.nlm.nih.gov/pubmed/37577491
http://dx.doi.org/10.1101/2023.08.03.551830
Descripción
Sumario:Diffuse optical methods including speckle contrast optical spectroscopy and tomography (SCOS and SCOT), use speckle contrast ([Formula: see text]) to measure deep blood flow. In order to design practical systems, parameters such as signal-to-noise ratio (SNR) and the effects of limited sampling of statistical quantities, should be considered. To that end, we have developed a method for simulating speckle contrast signals including effects of detector noise. The method was validated experimentally, and the simulations were used to study the effects of physical and experimental parameters on the accuracy and precision of [Formula: see text]. These results revealed that systematic detector effects resulted in decreased accuracy and precision of [Formula: see text] in the regime of low detected signals. The method can provide guidelines for the design and usage of SCOS and/or SCOT instruments.