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Epigenetic Factors and ncRNAs in Testicular Cancer

Testicular cancer is the most prevalent tumor among males aged 15 to 35, resulting in a significant number of newly diagnosed cases and fatalities annually. Non-coding RNAs (ncRNAs) have emerged as key regulators in various cellular processes and pathologies, including testicular cancer. Their invol...

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Autores principales: Nuñez-Corona, David, Contreras-Sanzón, Estefania, Puente-Rivera, Jonathan, Arreola, Rodrigo, Camacho-Nuez, Minerva, Cruz Santiago, José, Estrella-Parra, Edgar Antonio, Torres-Romero, Julio César, López-Camarillo, César, Alvarez-Sánchez, María Elizbeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418327/
https://www.ncbi.nlm.nih.gov/pubmed/37569569
http://dx.doi.org/10.3390/ijms241512194
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author Nuñez-Corona, David
Contreras-Sanzón, Estefania
Puente-Rivera, Jonathan
Arreola, Rodrigo
Camacho-Nuez, Minerva
Cruz Santiago, José
Estrella-Parra, Edgar Antonio
Torres-Romero, Julio César
López-Camarillo, César
Alvarez-Sánchez, María Elizbeth
author_facet Nuñez-Corona, David
Contreras-Sanzón, Estefania
Puente-Rivera, Jonathan
Arreola, Rodrigo
Camacho-Nuez, Minerva
Cruz Santiago, José
Estrella-Parra, Edgar Antonio
Torres-Romero, Julio César
López-Camarillo, César
Alvarez-Sánchez, María Elizbeth
author_sort Nuñez-Corona, David
collection PubMed
description Testicular cancer is the most prevalent tumor among males aged 15 to 35, resulting in a significant number of newly diagnosed cases and fatalities annually. Non-coding RNAs (ncRNAs) have emerged as key regulators in various cellular processes and pathologies, including testicular cancer. Their involvement in gene regulation, coding, decoding, and overall gene expression control suggests their potential as targets for alternative treatment approaches for this type of cancer. Furthermore, epigenetic modifications, such as histone modifications, DNA methylation, and the regulation by microRNA (miRNA), have been implicated in testicular tumor progression and treatment response. Epigenetics may also offer critical insights for prognostic evaluation and targeted therapies in patients with testicular germ cell tumors (TGCT). This comprehensive review aims to present the latest discoveries regarding the involvement of some proteins and ncRNAs, mainly miRNAs and lncRNA, in the epigenetic aspect of testicular cancer, emphasizing their relevance in pathogenesis and their potential, given the fact that their specific expression holds promise for prognostic evaluation and targeted therapies.
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spelling pubmed-104183272023-08-12 Epigenetic Factors and ncRNAs in Testicular Cancer Nuñez-Corona, David Contreras-Sanzón, Estefania Puente-Rivera, Jonathan Arreola, Rodrigo Camacho-Nuez, Minerva Cruz Santiago, José Estrella-Parra, Edgar Antonio Torres-Romero, Julio César López-Camarillo, César Alvarez-Sánchez, María Elizbeth Int J Mol Sci Review Testicular cancer is the most prevalent tumor among males aged 15 to 35, resulting in a significant number of newly diagnosed cases and fatalities annually. Non-coding RNAs (ncRNAs) have emerged as key regulators in various cellular processes and pathologies, including testicular cancer. Their involvement in gene regulation, coding, decoding, and overall gene expression control suggests their potential as targets for alternative treatment approaches for this type of cancer. Furthermore, epigenetic modifications, such as histone modifications, DNA methylation, and the regulation by microRNA (miRNA), have been implicated in testicular tumor progression and treatment response. Epigenetics may also offer critical insights for prognostic evaluation and targeted therapies in patients with testicular germ cell tumors (TGCT). This comprehensive review aims to present the latest discoveries regarding the involvement of some proteins and ncRNAs, mainly miRNAs and lncRNA, in the epigenetic aspect of testicular cancer, emphasizing their relevance in pathogenesis and their potential, given the fact that their specific expression holds promise for prognostic evaluation and targeted therapies. MDPI 2023-07-30 /pmc/articles/PMC10418327/ /pubmed/37569569 http://dx.doi.org/10.3390/ijms241512194 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nuñez-Corona, David
Contreras-Sanzón, Estefania
Puente-Rivera, Jonathan
Arreola, Rodrigo
Camacho-Nuez, Minerva
Cruz Santiago, José
Estrella-Parra, Edgar Antonio
Torres-Romero, Julio César
López-Camarillo, César
Alvarez-Sánchez, María Elizbeth
Epigenetic Factors and ncRNAs in Testicular Cancer
title Epigenetic Factors and ncRNAs in Testicular Cancer
title_full Epigenetic Factors and ncRNAs in Testicular Cancer
title_fullStr Epigenetic Factors and ncRNAs in Testicular Cancer
title_full_unstemmed Epigenetic Factors and ncRNAs in Testicular Cancer
title_short Epigenetic Factors and ncRNAs in Testicular Cancer
title_sort epigenetic factors and ncrnas in testicular cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418327/
https://www.ncbi.nlm.nih.gov/pubmed/37569569
http://dx.doi.org/10.3390/ijms241512194
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