Cargando…
Epigenetic Factors and ncRNAs in Testicular Cancer
Testicular cancer is the most prevalent tumor among males aged 15 to 35, resulting in a significant number of newly diagnosed cases and fatalities annually. Non-coding RNAs (ncRNAs) have emerged as key regulators in various cellular processes and pathologies, including testicular cancer. Their invol...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418327/ https://www.ncbi.nlm.nih.gov/pubmed/37569569 http://dx.doi.org/10.3390/ijms241512194 |
_version_ | 1785088237104005120 |
---|---|
author | Nuñez-Corona, David Contreras-Sanzón, Estefania Puente-Rivera, Jonathan Arreola, Rodrigo Camacho-Nuez, Minerva Cruz Santiago, José Estrella-Parra, Edgar Antonio Torres-Romero, Julio César López-Camarillo, César Alvarez-Sánchez, María Elizbeth |
author_facet | Nuñez-Corona, David Contreras-Sanzón, Estefania Puente-Rivera, Jonathan Arreola, Rodrigo Camacho-Nuez, Minerva Cruz Santiago, José Estrella-Parra, Edgar Antonio Torres-Romero, Julio César López-Camarillo, César Alvarez-Sánchez, María Elizbeth |
author_sort | Nuñez-Corona, David |
collection | PubMed |
description | Testicular cancer is the most prevalent tumor among males aged 15 to 35, resulting in a significant number of newly diagnosed cases and fatalities annually. Non-coding RNAs (ncRNAs) have emerged as key regulators in various cellular processes and pathologies, including testicular cancer. Their involvement in gene regulation, coding, decoding, and overall gene expression control suggests their potential as targets for alternative treatment approaches for this type of cancer. Furthermore, epigenetic modifications, such as histone modifications, DNA methylation, and the regulation by microRNA (miRNA), have been implicated in testicular tumor progression and treatment response. Epigenetics may also offer critical insights for prognostic evaluation and targeted therapies in patients with testicular germ cell tumors (TGCT). This comprehensive review aims to present the latest discoveries regarding the involvement of some proteins and ncRNAs, mainly miRNAs and lncRNA, in the epigenetic aspect of testicular cancer, emphasizing their relevance in pathogenesis and their potential, given the fact that their specific expression holds promise for prognostic evaluation and targeted therapies. |
format | Online Article Text |
id | pubmed-10418327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104183272023-08-12 Epigenetic Factors and ncRNAs in Testicular Cancer Nuñez-Corona, David Contreras-Sanzón, Estefania Puente-Rivera, Jonathan Arreola, Rodrigo Camacho-Nuez, Minerva Cruz Santiago, José Estrella-Parra, Edgar Antonio Torres-Romero, Julio César López-Camarillo, César Alvarez-Sánchez, María Elizbeth Int J Mol Sci Review Testicular cancer is the most prevalent tumor among males aged 15 to 35, resulting in a significant number of newly diagnosed cases and fatalities annually. Non-coding RNAs (ncRNAs) have emerged as key regulators in various cellular processes and pathologies, including testicular cancer. Their involvement in gene regulation, coding, decoding, and overall gene expression control suggests their potential as targets for alternative treatment approaches for this type of cancer. Furthermore, epigenetic modifications, such as histone modifications, DNA methylation, and the regulation by microRNA (miRNA), have been implicated in testicular tumor progression and treatment response. Epigenetics may also offer critical insights for prognostic evaluation and targeted therapies in patients with testicular germ cell tumors (TGCT). This comprehensive review aims to present the latest discoveries regarding the involvement of some proteins and ncRNAs, mainly miRNAs and lncRNA, in the epigenetic aspect of testicular cancer, emphasizing their relevance in pathogenesis and their potential, given the fact that their specific expression holds promise for prognostic evaluation and targeted therapies. MDPI 2023-07-30 /pmc/articles/PMC10418327/ /pubmed/37569569 http://dx.doi.org/10.3390/ijms241512194 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nuñez-Corona, David Contreras-Sanzón, Estefania Puente-Rivera, Jonathan Arreola, Rodrigo Camacho-Nuez, Minerva Cruz Santiago, José Estrella-Parra, Edgar Antonio Torres-Romero, Julio César López-Camarillo, César Alvarez-Sánchez, María Elizbeth Epigenetic Factors and ncRNAs in Testicular Cancer |
title | Epigenetic Factors and ncRNAs in Testicular Cancer |
title_full | Epigenetic Factors and ncRNAs in Testicular Cancer |
title_fullStr | Epigenetic Factors and ncRNAs in Testicular Cancer |
title_full_unstemmed | Epigenetic Factors and ncRNAs in Testicular Cancer |
title_short | Epigenetic Factors and ncRNAs in Testicular Cancer |
title_sort | epigenetic factors and ncrnas in testicular cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418327/ https://www.ncbi.nlm.nih.gov/pubmed/37569569 http://dx.doi.org/10.3390/ijms241512194 |
work_keys_str_mv | AT nunezcoronadavid epigeneticfactorsandncrnasintesticularcancer AT contrerassanzonestefania epigeneticfactorsandncrnasintesticularcancer AT puenteriverajonathan epigeneticfactorsandncrnasintesticularcancer AT arreolarodrigo epigeneticfactorsandncrnasintesticularcancer AT camachonuezminerva epigeneticfactorsandncrnasintesticularcancer AT cruzsantiagojose epigeneticfactorsandncrnasintesticularcancer AT estrellaparraedgarantonio epigeneticfactorsandncrnasintesticularcancer AT torresromerojuliocesar epigeneticfactorsandncrnasintesticularcancer AT lopezcamarillocesar epigeneticfactorsandncrnasintesticularcancer AT alvarezsanchezmariaelizbeth epigeneticfactorsandncrnasintesticularcancer |