JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer Formation

Janus tyrosine kinase 3 (JAK3) is primarily expressed in immune cells and is needed for signaling by the common gamma chain (γc) family of cytokines. Abnormal JAK3 signal transduction can manifest as hematological disorders, e.g., leukemia, severe combined immunodeficiency (SCID) and autoimmune dise...

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Detalles Bibliográficos
Autores principales: Rodriguez, Georgialina, Martinez, George Steven, Negrete, Omar Daniel, Sun, Shengjie, Guo, Wenhan, Xie, Yixin, Li, Lin, Xiao, Chuan, Ross, Jeremy Aaron, Kirken, Robert Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418363/
https://www.ncbi.nlm.nih.gov/pubmed/37569303
http://dx.doi.org/10.3390/ijms241511928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418363/
https://www.ncbi.nlm.nih.gov/pubmed/37569303
http://dx.doi.org/10.3390/ijms241511928

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